| http://purl.uniprot.org/citations/32620905 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32620905 | http://www.w3.org/2000/01/rdf-schema#comment | "The expanded polyglutamine (polyQ) tract form of ataxin-1 drives disease progression in spinocerebellar ataxia type 1 (SCA1). Although known to form distinctive intranuclear bodies, the cellular pathways and processes that polyQ-ataxin-1 influences remain poorly understood. Here we identify the direct and proximal partners constituting the interactome of ataxin-1[85Q] in Neuro-2a cells, pathways analyses indicating a significant enrichment of essential nuclear transporters, pointing to disruptions in nuclear transport processes in the presence of elevated levels of ataxin-1. Our direct assessments of nuclear transporters and their cargoes confirm these observations, revealing disrupted trafficking often with relocalisation of transporters and/or cargoes to ataxin-1[85Q] nuclear bodies. Analogous changes in importin-β1, nucleoporin 98 and nucleoporin 62 nuclear rim staining are observed in Purkinje cells of ATXN1[82Q] mice. The results highlight a disruption of multiple essential nuclear protein trafficking pathways by polyQ-ataxin-1, a key contribution to furthering understanding of pathogenic mechanisms initiated by polyQ tract proteins."xsd:string |
| http://purl.uniprot.org/citations/32620905 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-020-17145-0"xsd:string |
| http://purl.uniprot.org/citations/32620905 | http://purl.uniprot.org/core/author | "Bogoyevitch M.A."xsd:string |
| http://purl.uniprot.org/citations/32620905 | http://purl.uniprot.org/core/author | "Lee A."xsd:string |
| http://purl.uniprot.org/citations/32620905 | http://purl.uniprot.org/core/author | "Zhang S."xsd:string |
| http://purl.uniprot.org/citations/32620905 | http://purl.uniprot.org/core/author | "Yang P."xsd:string |
| http://purl.uniprot.org/citations/32620905 | http://purl.uniprot.org/core/author | "Orr H.T."xsd:string |
| http://purl.uniprot.org/citations/32620905 | http://purl.uniprot.org/core/author | "Williamson N.A."xsd:string |
| http://purl.uniprot.org/citations/32620905 | http://purl.uniprot.org/core/author | "Jans D.A."xsd:string |
| http://purl.uniprot.org/citations/32620905 | http://purl.uniprot.org/core/author | "Mok Y.F."xsd:string |
| http://purl.uniprot.org/citations/32620905 | http://purl.uniprot.org/core/author | "Duvick L."xsd:string |
| http://purl.uniprot.org/citations/32620905 | http://purl.uniprot.org/core/author | "Korlin-Downs A."xsd:string |
| http://purl.uniprot.org/citations/32620905 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32620905 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/32620905 | http://purl.uniprot.org/core/pages | "3343"xsd:string |
| http://purl.uniprot.org/citations/32620905 | http://purl.uniprot.org/core/title | "The ataxin-1 interactome reveals direct connection with multiple disrupted nuclear transport pathways."xsd:string |
| http://purl.uniprot.org/citations/32620905 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/32620905 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32620905 |
| http://purl.uniprot.org/citations/32620905 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32620905 |
| http://purl.uniprot.org/uniprot/#_P54254-mappedCitation-32620905 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32620905 |
| http://purl.uniprot.org/uniprot/#_J3QPR1-mappedCitation-32620905 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32620905 |
| http://purl.uniprot.org/uniprot/#_Q3U2W8-mappedCitation-32620905 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32620905 |
| http://purl.uniprot.org/uniprot/P54254 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/32620905 |
| http://purl.uniprot.org/uniprot/Q3U2W8 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/32620905 |