| http://purl.uniprot.org/citations/32625209 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32625209 | http://www.w3.org/2000/01/rdf-schema#comment | "The live attenuated Mycobacterium bovis strain, Bacille Calmette Guérin (BCG) is a potent innate immune stimulator. In the C57BL/6 mouse model of tuberculosis, BCG vaccination leads to a significant reduction of Mycobacterium tuberculosis burden after aerogenic infection. Our studies indicated that BCG induced protection against pulmonary tuberculosis was independent of T cells and present as early as 7 days after vaccination. This protection showed longevity, as it did not wane when conventional T cell and TNF-α deficient mice were infected 30 days post-vaccination. As BCG induced mycobacterial killing after 7 days, this study investigated the contributions of the innate immune system after BCG vaccination to better understand mechanisms required for mycobacterial killing. Subcutaneous BCG inoculation resulted in significant CD11b+F4/80+ monocyte subset recruitment into the lungs within 7 days. Further studies revealed that killing of mycobacteria was dependent on the viability of BCG, because irradiated BCG did not have the same effect. Although others have identified BCG as a facilitator of trained innate immunity, we found that BCG reduced the mycobacterial burden in the absence of mechanisms required for trained innate immunity, highlighting a role for macrophages and neutrophils for vaccine induced killing of M. tuberculosis."xsd:string |
| http://purl.uniprot.org/citations/32625209 | http://purl.org/dc/terms/identifier | "doi:10.3389/fimmu.2020.01202"xsd:string |
| http://purl.uniprot.org/citations/32625209 | http://purl.uniprot.org/core/author | "McLean J."xsd:string |
| http://purl.uniprot.org/citations/32625209 | http://purl.uniprot.org/core/author | "Izzo A.A."xsd:string |
| http://purl.uniprot.org/citations/32625209 | http://purl.uniprot.org/core/author | "Hagan C."xsd:string |
| http://purl.uniprot.org/citations/32625209 | http://purl.uniprot.org/core/author | "Izzo L."xsd:string |
| http://purl.uniprot.org/citations/32625209 | http://purl.uniprot.org/core/author | "Bickett T.E."xsd:string |
| http://purl.uniprot.org/citations/32625209 | http://purl.uniprot.org/core/author | "Creissen E."xsd:string |
| http://purl.uniprot.org/citations/32625209 | http://purl.uniprot.org/core/author | "Izzo A.J."xsd:string |
| http://purl.uniprot.org/citations/32625209 | http://purl.uniprot.org/core/author | "Silva Angulo F."xsd:string |
| http://purl.uniprot.org/citations/32625209 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32625209 | http://purl.uniprot.org/core/name | "Front Immunol"xsd:string |
| http://purl.uniprot.org/citations/32625209 | http://purl.uniprot.org/core/pages | "1202"xsd:string |
| http://purl.uniprot.org/citations/32625209 | http://purl.uniprot.org/core/title | "Characterizing the BCG Induced Macrophage and Neutrophil Mechanisms for Defense Against Mycobacterium tuberculosis."xsd:string |
| http://purl.uniprot.org/citations/32625209 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/32625209 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32625209 |
| http://purl.uniprot.org/citations/32625209 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32625209 |
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| http://purl.uniprot.org/uniprot/#_P06332-mappedCitation-32625209 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32625209 |