| http://purl.uniprot.org/citations/32629174 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32629174 | http://www.w3.org/2000/01/rdf-schema#comment | "Apoptotic chromatin condensation inducer in the nucleus (also referred as Acin1) was first characterized as an RNA-binding protein involved in apoptosis. In later reports, Acin1 was identified as an auxiliary component of the exon junction complex (EJC) which is assembled throughout pre-messenger RNA splicing. In this study, results of whole-transcriptome analyses revealed reduced expressions and reprogrammed splicing profiles of Acin1 transcripts throughout development of brown adipose tissues (BATs) that execute non-shivering thermogenesis in small rodents and infants by consuming lipids. Depletion of endogenous Acin1 isoforms led to activation of brown adipogenic signatures in mouse C3H10T1/2 fibroblasts. Nevertheless, overexpressions of the Acin1-L or Acin1-S isoform exerted discriminative influences on brown adipogenesis and reprogramming of the expression of serine/arginine-rich splicing factor 3 (SRSF3) through an alternative splicing-coupled nonsense-mediated decay mechanism in a sequence-specific manner. Moreover, the Acin1-SRSF3 axis constitutes a regulatory pathway that participates in the brown adipocyte-related splicing network. Taken together, the interplay between accessory EJC components and splicing regulators constitutes an emerging mechanism for differentially manipulating the activity of brown adipogenesis via alternative splicing network."xsd:string |
| http://purl.uniprot.org/citations/32629174 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbagrm.2020.194601"xsd:string |
| http://purl.uniprot.org/citations/32629174 | http://purl.uniprot.org/core/author | "Lin Y.C."xsd:string |
| http://purl.uniprot.org/citations/32629174 | http://purl.uniprot.org/core/author | "Lu Y.H."xsd:string |
| http://purl.uniprot.org/citations/32629174 | http://purl.uniprot.org/core/author | "Lee Y.C."xsd:string |
| http://purl.uniprot.org/citations/32629174 | http://purl.uniprot.org/core/author | "Lin J.C."xsd:string |
| http://purl.uniprot.org/citations/32629174 | http://purl.uniprot.org/core/author | "Hung C.S."xsd:string |
| http://purl.uniprot.org/citations/32629174 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32629174 | http://purl.uniprot.org/core/name | "Biochim Biophys Acta Gene Regul Mech"xsd:string |
| http://purl.uniprot.org/citations/32629174 | http://purl.uniprot.org/core/pages | "194601"xsd:string |
| http://purl.uniprot.org/citations/32629174 | http://purl.uniprot.org/core/title | "Altered expressions and splicing profiles of Acin1 transcripts differentially modulate brown adipogenesis through an alternative splicing mechanism."xsd:string |
| http://purl.uniprot.org/citations/32629174 | http://purl.uniprot.org/core/volume | "1863"xsd:string |
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