| http://purl.uniprot.org/citations/32630144 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32630144 | http://www.w3.org/2000/01/rdf-schema#comment | "The release of nucleotides during necrosis or apoptosis has been described to have both proinflammatory and anti-inflammatory effect on the surrounding cells. Here we describe how low concentrations of UTP and ATP applied during macrophage priming enhance IL-1β production when subsequently the NLRP3 inflammasome is activated in murine resident peritoneal macrophages. Deficiency or pharmacological inhibition of the purinergic receptor P2Y2 reverted the increase of IL-1β release induced by nucleotides. IL-1β increase was found dependent on the expression of Il1b gene and probably involving JNK activity. On the contrary, nucleotides decreased the production of a different proinflammatory cytokines such as TNF-α. These results suggest that nucleotides could shape the response of macrophages to obtain a unique proinflammatory signature that might be relevant in unrevealing specific inflammatory conditions."xsd:string |
| http://purl.uniprot.org/citations/32630144 | http://purl.org/dc/terms/identifier | "doi:10.3390/ijms21134686"xsd:string |
| http://purl.uniprot.org/citations/32630144 | http://purl.uniprot.org/core/author | "Pelegrin P."xsd:string |
| http://purl.uniprot.org/citations/32630144 | http://purl.uniprot.org/core/author | "Gomez A.I."xsd:string |
| http://purl.uniprot.org/citations/32630144 | http://purl.uniprot.org/core/author | "Banos M.C."xsd:string |
| http://purl.uniprot.org/citations/32630144 | http://purl.uniprot.org/core/author | "de la Rosa G."xsd:string |
| http://purl.uniprot.org/citations/32630144 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32630144 | http://purl.uniprot.org/core/name | "Int J Mol Sci"xsd:string |
| http://purl.uniprot.org/citations/32630144 | http://purl.uniprot.org/core/pages | "E4686"xsd:string |
| http://purl.uniprot.org/citations/32630144 | http://purl.uniprot.org/core/title | "Signaling Through Purinergic Receptor P2Ypisub>2pi/sub> Enhances Macrophage IL-1beta Production."xsd:string |
| http://purl.uniprot.org/citations/32630144 | http://purl.uniprot.org/core/volume | "21"xsd:string |
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