| http://purl.uniprot.org/citations/32631999 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32631999 | http://www.w3.org/2000/01/rdf-schema#comment | "The prefrontal cortex (PFC) plays a critical role in curbing impulsive behavior, but the underlying circuit mechanism remains incompletely understood. Here we show that a subset of dorsomedial PFC (dmPFC) layer 5 pyramidal neurons, which project to the subthalamic nucleus (STN) of the basal ganglia, play a key role in inhibiting impulsive responses in a go/no-go task. Projection-specific labeling and calcium imaging showed that the great majority of STN-projecting neurons were preferentially active in no-go trials when the mouse successfully withheld licking responses, but lateral hypothalamus (LH)-projecting neurons were more active in go trials with licking; visual cortex (V1)-projecting neurons showed only weak task-related activity. Optogenetic activation and inactivation of STN-projecting neurons reduced and increased inappropriate licking, respectively, partly through their direct innervation of the STN, but manipulating LH-projecting neurons had the opposite effects. These results identify a projection-defined subtype of PFC pyramidal neurons as key mediators of impulse control."xsd:string |
| http://purl.uniprot.org/citations/32631999 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.2000523117"xsd:string |
| http://purl.uniprot.org/citations/32631999 | http://purl.uniprot.org/core/author | "Li B."xsd:string |
| http://purl.uniprot.org/citations/32631999 | http://purl.uniprot.org/core/author | "Ma C."xsd:string |
| http://purl.uniprot.org/citations/32631999 | http://purl.uniprot.org/core/author | "Nguyen T.P."xsd:string |
| http://purl.uniprot.org/citations/32631999 | http://purl.uniprot.org/core/author | "Dan Y."xsd:string |
| http://purl.uniprot.org/citations/32631999 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32631999 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/32631999 | http://purl.uniprot.org/core/pages | "17278-17287"xsd:string |
| http://purl.uniprot.org/citations/32631999 | http://purl.uniprot.org/core/title | "Inhibition of impulsive action by projection-defined prefrontal pyramidal neurons."xsd:string |
| http://purl.uniprot.org/citations/32631999 | http://purl.uniprot.org/core/volume | "117"xsd:string |
| http://purl.uniprot.org/citations/32631999 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32631999 |
| http://purl.uniprot.org/citations/32631999 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32631999 |
| http://purl.uniprot.org/uniprot/#_Q9D3P9-mappedCitation-32631999 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32631999 |
| http://purl.uniprot.org/uniprot/Q9D3P9 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/32631999 |