| http://purl.uniprot.org/citations/32632011 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32632011 | http://www.w3.org/2000/01/rdf-schema#comment | "Rubicon is a potent negative regulator of autophagy and a potential target for autophagy-inducing therapeutics. Rubicon-mediated inhibition of autophagy requires the interaction of the C-terminal Rubicon homology (RH) domain of Rubicon with Rab7-GTP. Here we report the 2.8-Å crystal structure of the Rubicon RH domain in complex with Rab7-GTP. Our structure reveals a fold for the RH domain built around four zinc clusters. The switch regions of Rab7 insert into pockets on the surface of the RH domain in a mode that is distinct from those of other Rab-effector complexes. Rubicon residues at the dimer interface are required for Rubicon and Rab7 to colocalize in living cells. Mutation of Rubicon RH residues in the Rab7-binding site restores efficient autophagic flux in the presence of overexpressed Rubicon, validating the Rubicon RH domain as a promising therapeutic target."xsd:string |
| http://purl.uniprot.org/citations/32632011 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.2008030117"xsd:string |
| http://purl.uniprot.org/citations/32632011 | http://purl.uniprot.org/core/author | "DiMaio F."xsd:string |
| http://purl.uniprot.org/citations/32632011 | http://purl.uniprot.org/core/author | "Hurley J.H."xsd:string |
| http://purl.uniprot.org/citations/32632011 | http://purl.uniprot.org/core/author | "Yoshimori T."xsd:string |
| http://purl.uniprot.org/citations/32632011 | http://purl.uniprot.org/core/author | "Im Y.J."xsd:string |
| http://purl.uniprot.org/citations/32632011 | http://purl.uniprot.org/core/author | "Tabata K."xsd:string |
| http://purl.uniprot.org/citations/32632011 | http://purl.uniprot.org/core/author | "Hamasaki M."xsd:string |
| http://purl.uniprot.org/citations/32632011 | http://purl.uniprot.org/core/author | "Farrell D.P."xsd:string |
| http://purl.uniprot.org/citations/32632011 | http://purl.uniprot.org/core/author | "Bhargava H.K."xsd:string |
| http://purl.uniprot.org/citations/32632011 | http://purl.uniprot.org/core/author | "Anishchenko I."xsd:string |
| http://purl.uniprot.org/citations/32632011 | http://purl.uniprot.org/core/author | "Byck J.M."xsd:string |
| http://purl.uniprot.org/citations/32632011 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32632011 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/32632011 | http://purl.uniprot.org/core/pages | "17003-17010"xsd:string |
| http://purl.uniprot.org/citations/32632011 | http://purl.uniprot.org/core/title | "Structural basis for autophagy inhibition by the human Rubicon-Rab7 complex."xsd:string |
| http://purl.uniprot.org/citations/32632011 | http://purl.uniprot.org/core/volume | "117"xsd:string |
| http://purl.uniprot.org/citations/32632011 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32632011 |
| http://purl.uniprot.org/citations/32632011 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32632011 |
| http://purl.uniprot.org/uniprot/#_A0A158RFU6-mappedCitation-32632011 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32632011 |
| http://purl.uniprot.org/uniprot/#_A0A9L9PY84-mappedCitation-32632011 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32632011 |
| http://purl.uniprot.org/uniprot/#_B4DIJ0-mappedCitation-32632011 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32632011 |
| http://purl.uniprot.org/uniprot/#_B4DPH9-mappedCitation-32632011 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32632011 |
| http://purl.uniprot.org/uniprot/#_Q8N4U6-mappedCitation-32632011 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32632011 |