| http://purl.uniprot.org/citations/32632165 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32632165 | http://www.w3.org/2000/01/rdf-schema#comment | "CD4+ T lymphocytes consist of naïve, antigen-specific memory, and memory-phenotype (MP) cell compartments at homeostasis. We recently showed that MP cells exert innate-like effector function during host defense, but whether MP CD4+ T cells are functionally heterogeneous and, if so, what signals specify the differentiation of MP cell subpopulations under homeostatic conditions is still unclear. Here we characterize MP lymphocytes as consisting of T-bethigh, T-betlow, and T-bet- subsets, with innate, Th1-like effector activity exclusively associated with T-bethigh cells. We further show that the latter population depends on IL-12 produced by CD8α+ type 1 dendritic cells (DC1) for its differentiation. Finally, our data demonstrate that this tonic IL-12 production requires TLR-MyD88 signaling independent of foreign agonists, and is further enhanced by CD40-CD40L interactions between DC1 and CD4+ T lymphocytes. We propose that optimal differentiation of T-bethigh MP lymphocytes at homeostasis is driven by self-recognition signals at both the DC and Tcell levels."xsd:string |
| http://purl.uniprot.org/citations/32632165 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-020-17136-1"xsd:string |
| http://purl.uniprot.org/citations/32632165 | http://purl.uniprot.org/core/author | "Kim K.S."xsd:string |
| http://purl.uniprot.org/citations/32632165 | http://purl.uniprot.org/core/author | "Ishii N."xsd:string |
| http://purl.uniprot.org/citations/32632165 | http://purl.uniprot.org/core/author | "Yamane H."xsd:string |
| http://purl.uniprot.org/citations/32632165 | http://purl.uniprot.org/core/author | "Zhu J."xsd:string |
| http://purl.uniprot.org/citations/32632165 | http://purl.uniprot.org/core/author | "Sher A."xsd:string |
| http://purl.uniprot.org/citations/32632165 | http://purl.uniprot.org/core/author | "Trinchieri G."xsd:string |
| http://purl.uniprot.org/citations/32632165 | http://purl.uniprot.org/core/author | "Yi J."xsd:string |
| http://purl.uniprot.org/citations/32632165 | http://purl.uniprot.org/core/author | "Kawabe T."xsd:string |
| http://purl.uniprot.org/citations/32632165 | http://purl.uniprot.org/core/author | "Fang D."xsd:string |
| http://purl.uniprot.org/citations/32632165 | http://purl.uniprot.org/core/author | "Kawajiri A."xsd:string |
| http://purl.uniprot.org/citations/32632165 | http://purl.uniprot.org/core/author | "Jankovic D."xsd:string |
| http://purl.uniprot.org/citations/32632165 | http://purl.uniprot.org/core/author | "Hilligan K."xsd:string |
| http://purl.uniprot.org/citations/32632165 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32632165 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/32632165 | http://purl.uniprot.org/core/pages | "3366"xsd:string |
| http://purl.uniprot.org/citations/32632165 | http://purl.uniprot.org/core/title | "Requirements for the differentiation of innate T-bethigh memory-phenotype CD4+ T lymphocytes under steady state."xsd:string |
| http://purl.uniprot.org/citations/32632165 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/32632165 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32632165 |
| http://purl.uniprot.org/citations/32632165 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32632165 |
| http://purl.uniprot.org/uniprot/#_Q0PM15-mappedCitation-32632165 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32632165 |
| http://purl.uniprot.org/uniprot/#_Q0PM16-mappedCitation-32632165 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32632165 |
| http://purl.uniprot.org/uniprot/#_A0A7R8C347-mappedCitation-32632165 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32632165 |