| http://purl.uniprot.org/citations/32632545 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32632545 | http://www.w3.org/2000/01/rdf-schema#comment | "IL-22 is known to mediate inflammation in psoriasis, while IL-22 binding protein (IL-22BP) binds IL-22 to suppress IL-22 signaling. However, the function of IL-22 in regulating apoptosis in psoriasis remains poorly understood. In this study, we found that IL-22/IL-22R1 in lesional skin and IL-22 in serum from psoriatic patients were highly upregulated compared with healthy controls, while IL-22BP was not changed. Correlations between IL-22/IL-22R1 levels and the thickness of psoriatic lesions suggested that IL-22 might positively regulate abnormal hyperplasia in psoriasis. Apoptotic keratinocytes were increased only in stratum corneum, but not in spinous and basal layers of psoriasis. Moreover, IL-22 promoted cell viability in human epidermal keratinocytes (HEKs). The apoptosis induced by TNF-α and IFN-γ was inhibited in HEKs treated with IL-22, since that IL-22 upregulated Bcl-xL and downregulated Bax production in HEKs in the presence of TNF-α and IFN-γ. In addition, IL-22BP could counteract the anti-apoptotic effect of IL-22. Our finding demonstrates that IL-22 might play an anti-apoptosis role on keratinocytes to balance cell proliferation and apoptosis in psoriatic epidermis."xsd:string |
| http://purl.uniprot.org/citations/32632545 | http://purl.org/dc/terms/identifier | "doi:10.1007/s10495-020-01623-3"xsd:string |
| http://purl.uniprot.org/citations/32632545 | http://purl.uniprot.org/core/author | "Hou W."xsd:string |
| http://purl.uniprot.org/citations/32632545 | http://purl.uniprot.org/core/author | "Han D."xsd:string |
| http://purl.uniprot.org/citations/32632545 | http://purl.uniprot.org/core/author | "Lu S."xsd:string |
| http://purl.uniprot.org/citations/32632545 | http://purl.uniprot.org/core/author | "Li F."xsd:string |
| http://purl.uniprot.org/citations/32632545 | http://purl.uniprot.org/core/author | "Wang L."xsd:string |
| http://purl.uniprot.org/citations/32632545 | http://purl.uniprot.org/core/author | "Zhou Y."xsd:string |
| http://purl.uniprot.org/citations/32632545 | http://purl.uniprot.org/core/author | "Wang B."xsd:string |
| http://purl.uniprot.org/citations/32632545 | http://purl.uniprot.org/core/author | "Zhu W."xsd:string |
| http://purl.uniprot.org/citations/32632545 | http://purl.uniprot.org/core/author | "Meng L."xsd:string |
| http://purl.uniprot.org/citations/32632545 | http://purl.uniprot.org/core/author | "Mou K."xsd:string |
| http://purl.uniprot.org/citations/32632545 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32632545 | http://purl.uniprot.org/core/name | "Apoptosis"xsd:string |
| http://purl.uniprot.org/citations/32632545 | http://purl.uniprot.org/core/pages | "663-673"xsd:string |
| http://purl.uniprot.org/citations/32632545 | http://purl.uniprot.org/core/title | "Elevated IL-22 in psoriasis plays an anti-apoptotic role in keratinocytes through mediating Bcl-xL/Bax."xsd:string |
| http://purl.uniprot.org/citations/32632545 | http://purl.uniprot.org/core/volume | "25"xsd:string |
| http://purl.uniprot.org/citations/32632545 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32632545 |
| http://purl.uniprot.org/citations/32632545 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32632545 |
| http://purl.uniprot.org/uniprot/#_Q07817-mappedCitation-32632545 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32632545 |
| http://purl.uniprot.org/uniprot/#_A0A7R8C389-mappedCitation-32632545 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32632545 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z3C5-mappedCitation-32632545 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32632545 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z3D2-mappedCitation-32632545 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32632545 |
| http://purl.uniprot.org/uniprot/#_Q5TE63-mappedCitation-32632545 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32632545 |