| http://purl.uniprot.org/citations/32637151 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32637151 | http://www.w3.org/2000/01/rdf-schema#comment | "Genetic robustness is an important characteristic to tolerate genetic or nongenetic perturbations and ensure phenotypic stability. Morphogens, a type of evolutionarily conserved diffusible molecules, govern tissue patterns in a direction-dependent or concentration-dependent manner by differentially regulating downstream gene expression. However, whether the morphogen-directed gene regulatory network possesses genetic robustness remains elusive. In the present study, we collected 4217 morphogen-responsive genes along A-P axis of Drosophila wing discs from the RNA-seq data, and clustered them into 12 modules. By applying mathematical model to the measured data, we constructed a gene modular network (GMN) to decipher the module regulatory interactions and robustness in morphogen-directed development. The computational analyses on asymptotical dynamics of this GMN demonstrated that this morphogen-directed GMN is robust to tolerate a majority of genetic perturbations, which has been further validated by biological experiments. Furthermore, besides the genetic alterations, we further demonstrated that this morphogen-directed GMN can well tolerate nongenetic perturbations (Hh production changes) via computational analyses and experimental validation. Therefore, these findings clearly indicate that the morphogen-directed GMN is robust in response to perturbations and is important for Drosophila to ensure the proper tissue patterning in wing disc."xsd:string |
| http://purl.uniprot.org/citations/32637151 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41421-020-0173-z"xsd:string |
| http://purl.uniprot.org/citations/32637151 | http://purl.uniprot.org/core/author | "Chen L."xsd:string |
| http://purl.uniprot.org/citations/32637151 | http://purl.uniprot.org/core/author | "Fan J."xsd:string |
| http://purl.uniprot.org/citations/32637151 | http://purl.uniprot.org/core/author | "Lu Y."xsd:string |
| http://purl.uniprot.org/citations/32637151 | http://purl.uniprot.org/core/author | "Wu H."xsd:string |
| http://purl.uniprot.org/citations/32637151 | http://purl.uniprot.org/core/author | "Zhang S."xsd:string |
| http://purl.uniprot.org/citations/32637151 | http://purl.uniprot.org/core/author | "Zhao J."xsd:string |
| http://purl.uniprot.org/citations/32637151 | http://purl.uniprot.org/core/author | "Zhao Y."xsd:string |
| http://purl.uniprot.org/citations/32637151 | http://purl.uniprot.org/core/author | "Lv X."xsd:string |
| http://purl.uniprot.org/citations/32637151 | http://purl.uniprot.org/core/author | "Zeng T."xsd:string |
| http://purl.uniprot.org/citations/32637151 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32637151 | http://purl.uniprot.org/core/name | "Cell Discov"xsd:string |
| http://purl.uniprot.org/citations/32637151 | http://purl.uniprot.org/core/pages | "43"xsd:string |
| http://purl.uniprot.org/citations/32637151 | http://purl.uniprot.org/core/title | "Analysis on gene modular network reveals morphogen-directed development robustness in Drosophila."xsd:string |
| http://purl.uniprot.org/citations/32637151 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/32637151 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32637151 |
| http://purl.uniprot.org/citations/32637151 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32637151 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KFQ1-mappedCitation-32637151 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32637151 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KFW0-mappedCitation-32637151 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32637151 |
| http://purl.uniprot.org/uniprot/#_P56721-mappedCitation-32637151 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32637151 |
| http://purl.uniprot.org/uniprot/#_A8DYD9-mappedCitation-32637151 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32637151 |
| http://purl.uniprot.org/uniprot/#_A4V3W1-mappedCitation-32637151 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32637151 |
| http://purl.uniprot.org/uniprot/#_A4V3W2-mappedCitation-32637151 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32637151 |