| http://purl.uniprot.org/citations/32639881 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32639881 | http://www.w3.org/2000/01/rdf-schema#comment | "Atrial fibrillation (AF) is frequently associated with increased inflammatory response characterized by infiltration of monocytes/macrophages. The chemokine receptor CXCR-2 is a critical regulator of monocyte mobilization in hypertension and cardiac remodeling, but it is not known whether CXCR-2 is involved in the development of hypertensive AF. AF was induced by infusion of Ang II (angiotensin II; 2000 ng/kg per minute) for 3 weeks in male C57BL/6 wild-type mice, CXCR-2 knockout mice, bone marrow-reconstituted chimeric mice, and mice treated with the CXCR-2 inhibitor SB225002. Microarray analysis revealed that 4 chemokine ligands of CXCR-2 were significantly upregulated in the atria during 3 weeks of Ang II infusion. CXCR-2 expression and the number of CXCR2+ immune cells markedly increased in Ang II-infused atria in a time-dependent manner. Moreover, Ang II-infused wild-type mice had increased blood pressure, AF inducibility, atrial diameter, fibrosis, infiltration of macrophages, and superoxide production compared with saline-treated wild-type mice, whereas these effects were significantly attenuated in CXCR-2 knockout mice and wild-type mice transplanted with CXCR-2-deficient bone marrow cells or treated with SB225002. Moreover, circulating blood CXCL-1 levels and CXCR2+ monocyte counts were higher and associated with AF in human patients (n=31) compared with sinus rhythm controls (n=31). In summary, this study identified a novel role for CXCR-2 in driving monocyte infiltration of the atria, which accelerates atrial remodeling and AF after hypertension. Blocking CXCR-2 activation may serve as a new therapeutic strategy for AF."xsd:string |
| http://purl.uniprot.org/citations/32639881 | http://purl.org/dc/terms/identifier | "doi:10.1161/hypertensionaha.120.14698"xsd:string |
| http://purl.uniprot.org/citations/32639881 | http://purl.uniprot.org/core/author | "Chen C."xsd:string |
| http://purl.uniprot.org/citations/32639881 | http://purl.uniprot.org/core/author | "Han X."xsd:string |
| http://purl.uniprot.org/citations/32639881 | http://purl.uniprot.org/core/author | "Liu Y."xsd:string |
| http://purl.uniprot.org/citations/32639881 | http://purl.uniprot.org/core/author | "Li H.H."xsd:string |
| http://purl.uniprot.org/citations/32639881 | http://purl.uniprot.org/core/author | "Yang J."xsd:string |
| http://purl.uniprot.org/citations/32639881 | http://purl.uniprot.org/core/author | "Yan X."xsd:string |
| http://purl.uniprot.org/citations/32639881 | http://purl.uniprot.org/core/author | "Teng F."xsd:string |
| http://purl.uniprot.org/citations/32639881 | http://purl.uniprot.org/core/author | "Zhang Y.L."xsd:string |
| http://purl.uniprot.org/citations/32639881 | http://purl.uniprot.org/core/author | "Xia Y.L."xsd:string |
| http://purl.uniprot.org/citations/32639881 | http://purl.uniprot.org/core/author | "Guo S.B."xsd:string |
| http://purl.uniprot.org/citations/32639881 | http://purl.uniprot.org/core/author | "Cao H.J."xsd:string |
| http://purl.uniprot.org/citations/32639881 | http://purl.uniprot.org/core/author | "Li P.B."xsd:string |
| http://purl.uniprot.org/citations/32639881 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32639881 | http://purl.uniprot.org/core/name | "Hypertension"xsd:string |
| http://purl.uniprot.org/citations/32639881 | http://purl.uniprot.org/core/pages | "381-392"xsd:string |
| http://purl.uniprot.org/citations/32639881 | http://purl.uniprot.org/core/title | "Chemokine Receptor CXCR-2 Initiates Atrial Fibrillation by Triggering Monocyte Mobilization in Mice."xsd:string |
| http://purl.uniprot.org/citations/32639881 | http://purl.uniprot.org/core/volume | "76"xsd:string |
| http://purl.uniprot.org/citations/32639881 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32639881 |
| http://purl.uniprot.org/citations/32639881 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32639881 |
| http://purl.uniprot.org/uniprot/#_P35343-mappedCitation-32639881 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32639881 |
| http://purl.uniprot.org/uniprot/P35343 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/32639881 |