| http://purl.uniprot.org/citations/32640226 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32640226 | http://www.w3.org/2000/01/rdf-schema#comment | "Mitogen-activated protein kinase kinase kinase kinases (MAP4Ks) constitute a mammalian STE20-like serine/threonine kinase subfamily. Recent studies provide substantial evidence for MAP4K family kinases in the Hippo pathway regulation, suggesting a broad role of MAP4Ks in human physiology and diseases. However, a comprehensive analysis of the regulators and effectors for this key kinase family has not been fully achieved. Using a proteomic approach, we define the protein-protein interaction network for human MAP4K family kinases and reveal diverse cellular signaling events involving this important kinase family. Through it, we identify a STRIPAK complex component, STRN4, as a generic binding partner for MAP4Ks and a key regulator of the Hippo pathway in endometrial cancer development. Taken together, the results of our study not only generate a rich resource for further characterizing human MAP4K family kinases in numerous biological processes but also dissect the STRIPAK-mediated regulation of MAP4Ks in the Hippo pathway."xsd:string |
| http://purl.uniprot.org/citations/32640226 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2020.107860"xsd:string |
| http://purl.uniprot.org/citations/32640226 | http://purl.uniprot.org/core/author | "Li X."xsd:string |
| http://purl.uniprot.org/citations/32640226 | http://purl.uniprot.org/core/author | "Wang W."xsd:string |
| http://purl.uniprot.org/citations/32640226 | http://purl.uniprot.org/core/author | "Yang B."xsd:string |
| http://purl.uniprot.org/citations/32640226 | http://purl.uniprot.org/core/author | "Han H."xsd:string |
| http://purl.uniprot.org/citations/32640226 | http://purl.uniprot.org/core/author | "Seo G."xsd:string |
| http://purl.uniprot.org/citations/32640226 | http://purl.uniprot.org/core/author | "Vargas R.E."xsd:string |
| http://purl.uniprot.org/citations/32640226 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32640226 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/32640226 | http://purl.uniprot.org/core/pages | "107860"xsd:string |
| http://purl.uniprot.org/citations/32640226 | http://purl.uniprot.org/core/title | "MAP4K Interactome Reveals STRN4 as a Key STRIPAK Complex Component in Hippo Pathway Regulation."xsd:string |
| http://purl.uniprot.org/citations/32640226 | http://purl.uniprot.org/core/volume | "32"xsd:string |
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