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http://purl.uniprot.org/citations/32640236http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/32640236http://www.w3.org/2000/01/rdf-schema#comment"Craniofacial abnormalities often involve sutures, the growth centers of the skull. To characterize the organization and processes governing their development, we profile the murine frontal suture, a model for sutural growth and fusion, at the tissue- and single-cell level on embryonic days (E)16.5 and E18.5. For the wild-type suture, bulk RNA sequencing (RNA-seq) analysis identifies mesenchyme-, osteogenic front-, and stage-enriched genes and biological processes, as well as alternative splicing events modifying the extracellular matrix. Single-cell RNA-seq analysis distinguishes multiple subpopulations, of which five define a mesenchyme-osteoblast differentiation trajectory and show variation along the anteroposterior axis. Similar analyses of in vivo mouse models of impaired frontal suturogenesis in Saethre-Chotzen and Apert syndromes, Twist1+/- and Fgfr2+/S252W, demonstrate distinct transcriptional changes involving angiogenesis and ribogenesis, respectively. Co-expression network analysis reveals gene expression modules from which we validate key driver genes regulating osteoblast differentiation. Our study provides a global approach to gain insights into suturogenesis."xsd:string
http://purl.uniprot.org/citations/32640236http://purl.org/dc/terms/identifier"doi:10.1016/j.celrep.2020.107871"xsd:string
http://purl.uniprot.org/citations/32640236http://purl.uniprot.org/core/author"Zhou X."xsd:string
http://purl.uniprot.org/citations/32640236http://purl.uniprot.org/core/author"Zhang B."xsd:string
http://purl.uniprot.org/citations/32640236http://purl.uniprot.org/core/author"Rivera J."xsd:string
http://purl.uniprot.org/citations/32640236http://purl.uniprot.org/core/author"Lu N."xsd:string
http://purl.uniprot.org/citations/32640236http://purl.uniprot.org/core/author"van Bakel H."xsd:string
http://purl.uniprot.org/citations/32640236http://purl.uniprot.org/core/author"Gonzalez-Reiche A.S."xsd:string
http://purl.uniprot.org/citations/32640236http://purl.uniprot.org/core/author"Jabs E.W."xsd:string
http://purl.uniprot.org/citations/32640236http://purl.uniprot.org/core/author"Pinto D."xsd:string
http://purl.uniprot.org/citations/32640236http://purl.uniprot.org/core/author"Potter S.S."xsd:string
http://purl.uniprot.org/citations/32640236http://purl.uniprot.org/core/author"Donovan M.J."xsd:string
http://purl.uniprot.org/citations/32640236http://purl.uniprot.org/core/author"Sebra R."xsd:string
http://purl.uniprot.org/citations/32640236http://purl.uniprot.org/core/author"Holmes G."xsd:string
http://purl.uniprot.org/citations/32640236http://purl.uniprot.org/core/author"Williams A.A."xsd:string
http://purl.uniprot.org/citations/32640236http://purl.uniprot.org/core/author"Kriti D."xsd:string
http://purl.uniprot.org/citations/32640236http://purl.uniprot.org/core/date"2020"xsd:gYear
http://purl.uniprot.org/citations/32640236http://purl.uniprot.org/core/name"Cell Rep"xsd:string
http://purl.uniprot.org/citations/32640236http://purl.uniprot.org/core/pages"107871"xsd:string
http://purl.uniprot.org/citations/32640236http://purl.uniprot.org/core/title"Integrated Transcriptome and Network Analysis Reveals Spatiotemporal Dynamics of Calvarial Suturogenesis."xsd:string
http://purl.uniprot.org/citations/32640236http://purl.uniprot.org/core/volume"32"xsd:string
http://purl.uniprot.org/citations/32640236http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/32640236
http://purl.uniprot.org/citations/32640236http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/32640236
http://purl.uniprot.org/uniprot/#_A0A0N4SUZ7-mappedCitation-32640236http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/32640236