| http://purl.uniprot.org/citations/32644192 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32644192 | http://www.w3.org/2000/01/rdf-schema#comment | "Plasmacytoid dendritic cells (DCs) are reported to induce robust type-I interferon (IFN) response, whereas cDC1 DCs develop moderate type-I IFN response upon TLR9 stimulation. It is very interesting to understand how this signaling under TLR9 is tightly regulated for the induction of type-I IFNs. Here, we report co-repressor protein NCoR1 as the major factor fine-tuning the signaling pathways regulating IFN-β expression under TLR9 in cDC1 DCs. We found that NCoR1 knockdown induced a robust IFN-β-mediated antiviral response upon TLR9 activation in cDC1 DCs. At the molecular level, we showed that NCoR1 directly repressed MyD88-IRF7 signaling axis in cDC1 cells. Therefore, NCoR1 depletion enhanced pIRF7 levels, IFN-β secretion, and downstream pSTAT1-pSTAT2 signaling, leading to sustained induction of IFN stimulatory genes. Integrative genomic analysis depicted strong enrichment of an antiviral gene-module in CpG-activated NCoR1 knockdown DCs upon TLR9 activation. Moreover, we confirmed our findings in primary DCs derived from splenocytes of WT and NCoR1 DC-/- animals, which showed protection from Sendai and Vesicular Stomatitis viruses upon CpG activation. Ultimately, we identified that NCoR1-HDAC3 complex is involved in repressing the type-I IFN response in cDC1 DCs."xsd:string |
| http://purl.uniprot.org/citations/32644192 | http://purl.org/dc/terms/identifier | "doi:10.1002/eji.202048566"xsd:string |
| http://purl.uniprot.org/citations/32644192 | http://purl.uniprot.org/core/author | "Gupta B."xsd:string |
| http://purl.uniprot.org/citations/32644192 | http://purl.uniprot.org/core/author | "Ahad A."xsd:string |
| http://purl.uniprot.org/citations/32644192 | http://purl.uniprot.org/core/author | "Raghav S.K."xsd:string |
| http://purl.uniprot.org/citations/32644192 | http://purl.uniprot.org/core/author | "Garcin D."xsd:string |
| http://purl.uniprot.org/citations/32644192 | http://purl.uniprot.org/core/author | "Sen K."xsd:string |
| http://purl.uniprot.org/citations/32644192 | http://purl.uniprot.org/core/author | "Mishra G.P."xsd:string |
| http://purl.uniprot.org/citations/32644192 | http://purl.uniprot.org/core/author | "Acha-Orbea H."xsd:string |
| http://purl.uniprot.org/citations/32644192 | http://purl.uniprot.org/core/author | "Smita S."xsd:string |
| http://purl.uniprot.org/citations/32644192 | http://purl.uniprot.org/core/author | "Biswas V.K."xsd:string |
| http://purl.uniprot.org/citations/32644192 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32644192 | http://purl.uniprot.org/core/name | "Eur J Immunol"xsd:string |
| http://purl.uniprot.org/citations/32644192 | http://purl.uniprot.org/core/pages | "1959-1975"xsd:string |
| http://purl.uniprot.org/citations/32644192 | http://purl.uniprot.org/core/title | "NCoR1 fine-tunes type-I IFN response in cDC1 dendritic cells by directly regulating Myd88-IRF7 axis under TLR9."xsd:string |
| http://purl.uniprot.org/citations/32644192 | http://purl.uniprot.org/core/volume | "50"xsd:string |
| http://purl.uniprot.org/citations/32644192 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32644192 |
| http://purl.uniprot.org/citations/32644192 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32644192 |
| http://purl.uniprot.org/uniprot/#_E9Q9Y2-mappedCitation-32644192 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32644192 |
| http://purl.uniprot.org/uniprot/#_E0CYX5-mappedCitation-32644192 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32644192 |
| http://purl.uniprot.org/uniprot/#_Q0PM15-mappedCitation-32644192 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32644192 |
| http://purl.uniprot.org/uniprot/#_Q0PM16-mappedCitation-32644192 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32644192 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GRH7-mappedCitation-32644192 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32644192 |
| http://purl.uniprot.org/uniprot/#_A0A1S5WLE4-mappedCitation-32644192 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32644192 |