| http://purl.uniprot.org/citations/32648369 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32648369 | http://www.w3.org/2000/01/rdf-schema#comment | "The age-associated decline of adult stem cell function is closely related to the decline in tissue function and age-related diseases. However, the underlying mechanisms that ultimately lead to the observed functional decline of stem cells still remain largely unexplored. This study investigated Drosophila midguts and found a continuous downregulation of lipoic acid synthase, which encodes the key enzyme for the endogenous synthesis of alpha-lipoic acid (ALA), upon aging. Importantly, orally administration of ALA significantly reversed the age-associated hyperproliferation of intestinal stem cells (ISCs) and the observed decline of intestinal function, thus extending the lifespan of Drosophila. This study reports that ALA reverses age-associated ISC dysfunction by promoting the activation of the endocytosis-autophagy network, which decreases in aged ISCs. Moreover, this study suggests that ALA may be used as a safe and effective anti-aging compound for the treatment of ISC-dysfunction-related diseases and for the promotion of healthy aging in humans."xsd:string |
| http://purl.uniprot.org/citations/32648369 | http://purl.org/dc/terms/identifier | "doi:10.15252/embr.201949583"xsd:string |
| http://purl.uniprot.org/citations/32648369 | http://purl.uniprot.org/core/author | "Chen H."xsd:string |
| http://purl.uniprot.org/citations/32648369 | http://purl.uniprot.org/core/author | "Liu Z."xsd:string |
| http://purl.uniprot.org/citations/32648369 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
| http://purl.uniprot.org/citations/32648369 | http://purl.uniprot.org/core/author | "Li X."xsd:string |
| http://purl.uniprot.org/citations/32648369 | http://purl.uniprot.org/core/author | "Qiao Y."xsd:string |
| http://purl.uniprot.org/citations/32648369 | http://purl.uniprot.org/core/author | "Zhou J."xsd:string |
| http://purl.uniprot.org/citations/32648369 | http://purl.uniprot.org/core/author | "Du G."xsd:string |
| http://purl.uniprot.org/citations/32648369 | http://purl.uniprot.org/core/author | "Zhuo Z."xsd:string |
| http://purl.uniprot.org/citations/32648369 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32648369 | http://purl.uniprot.org/core/name | "EMBO Rep"xsd:string |
| http://purl.uniprot.org/citations/32648369 | http://purl.uniprot.org/core/pages | "e49583"xsd:string |
| http://purl.uniprot.org/citations/32648369 | http://purl.uniprot.org/core/title | "Lipoic acid rejuvenates aged intestinal stem cells by preventing age-associated endosome reduction."xsd:string |
| http://purl.uniprot.org/citations/32648369 | http://purl.uniprot.org/core/volume | "21"xsd:string |
| http://purl.uniprot.org/citations/32648369 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32648369 |
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