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http://purl.uniprot.org/citations/32653519http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/32653519http://www.w3.org/2000/01/rdf-schema#comment"

Aims

Hepatocellular carcinoma (HCC), one of the most common cancer, causes the fourth cancer-related deaths around the world. N6-methyladenosine (m6A) has been reported to mediate circRNA translation in cancer biology. However, the mechanisms by which m6A and circRNA in post-transcriptional in HCC progression remain poorly understood. This study aimed to explore the mechanisms by which m6A and circRNA in post-transcriptional in HCC progression.

Main methods

circ_KIAA1429 (hsa_circ_0084922) expression profiles in matched normal and HCC tissues were detected using microarray analysis. The biological roles of circ_KIAA1429 in progression of HCCC were measured both in vitro and in vivo.

Key findings

In this study, we found hsa_circ_0084922, which came from KIAA1429, named circ_KIAA1429, was upregulated in HCC cells and tumor tissues. Overexpression of circ_KIAA1429 can facilitate HCC migration, invasion, and EMT process. However, knockdown of circ_KIAA1429 lead to the opposite results. Furthermore, it was demonstrated that Zeb1 was the downstream target of circ_KIAA1429. Up-regulation of Zeb1 led to HCC cells metastasis induced by circ_KIAA1429. In addition, YTHDF3 enhanced Zeb1 mRNA stability via an m6A dependent manner.

Significance

This study revealed that circ_KIAA1429 could accelerate HCC advancement, maintained the expression of Zeb1 through the mechanism of m6A-YTHDF3-Zeb1 in HCC. What's more, it might represent a potential therapeutic target in HCC."xsd:string
http://purl.uniprot.org/citations/32653519http://purl.org/dc/terms/identifier"doi:10.1016/j.lfs.2020.118082"xsd:string
http://purl.uniprot.org/citations/32653519http://purl.uniprot.org/core/author"Han S."xsd:string
http://purl.uniprot.org/citations/32653519http://purl.uniprot.org/core/author"Yang J."xsd:string
http://purl.uniprot.org/citations/32653519http://purl.uniprot.org/core/author"Wang M."xsd:string
http://purl.uniprot.org/citations/32653519http://purl.uniprot.org/core/author"Yang Y."xsd:string
http://purl.uniprot.org/citations/32653519http://purl.uniprot.org/core/author"Yang J.'"xsd:string
http://purl.uniprot.org/citations/32653519http://purl.uniprot.org/core/date"2020"xsd:gYear
http://purl.uniprot.org/citations/32653519http://purl.uniprot.org/core/name"Life Sci"xsd:string
http://purl.uniprot.org/citations/32653519http://purl.uniprot.org/core/pages"118082"xsd:string
http://purl.uniprot.org/citations/32653519http://purl.uniprot.org/core/title"circ_KIAA1429 accelerates hepatocellular carcinoma advancement through the mechanism of m6A-YTHDF3-Zeb1."xsd:string
http://purl.uniprot.org/citations/32653519http://purl.uniprot.org/core/volume"257"xsd:string
http://purl.uniprot.org/citations/32653519http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/32653519
http://purl.uniprot.org/citations/32653519http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/32653519
http://purl.uniprot.org/uniprot/#_Q69YN4-mappedCitation-32653519http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/32653519
http://purl.uniprot.org/uniprot/Q69YN4http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/32653519