| http://purl.uniprot.org/citations/32658600 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32658600 | http://www.w3.org/2000/01/rdf-schema#comment | "Circular RNAs (circRNAs) are closely associated with the development of non-small cell lung cancer (NSCLC); however, it is still unclear whether circular RNA circ-LDLRAD3 participated in the regulation of NSCLC progression. In this study, we found that circ-LDLRAD3 was high-expressed and miR-137 was low-expressed in NSCLC tissues and cells compared to their normal counterparts, which showed negative correlations in NSCLC tissues. Further experiments validated that miR-137 could be sponged and inhibited by circ-LDLRAD3 in NSCLC cells. In addition, knock-down of circ-LDLRAD3 and miR-137 overexpression promoted NSCLC cell apoptosis, and inhibited cell proliferation and invasion. Similarly, upregulation of circ-LDLRAD3 or miR-137 ablation had opposite effects on the above cell functions. Besides, the glutamine transporter SLC1A5 was validated to be the downstream target of circ-LDLRAD3 and miR-137, and upregulated circ-LDLRAD3 increased SLC1A5 expression levels by downregulating miR-137. Furthermore, the effects of downregulated circ-LDLRAD3 on cell proliferation, apoptosis and mobility were all reversed by knocking down miR-137 and overexpressing SLC1A5. Taken together, this in vitro study found that knock-down of circ-LDLRAD3 inhibited the development of NSCLC by regulating miR-137/SLC1A5 axis."xsd:string |
| http://purl.uniprot.org/citations/32658600 | http://purl.org/dc/terms/identifier | "doi:10.1080/15476286.2020.1789819"xsd:string |
| http://purl.uniprot.org/citations/32658600 | http://purl.uniprot.org/core/author | "Gao X."xsd:string |
| http://purl.uniprot.org/citations/32658600 | http://purl.uniprot.org/core/author | "Jiang J."xsd:string |
| http://purl.uniprot.org/citations/32658600 | http://purl.uniprot.org/core/author | "Hong W."xsd:string |
| http://purl.uniprot.org/citations/32658600 | http://purl.uniprot.org/core/author | "Zhao F."xsd:string |
| http://purl.uniprot.org/citations/32658600 | http://purl.uniprot.org/core/author | "Xue M."xsd:string |
| http://purl.uniprot.org/citations/32658600 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32658600 | http://purl.uniprot.org/core/name | "RNA Biol"xsd:string |
| http://purl.uniprot.org/citations/32658600 | http://purl.uniprot.org/core/pages | "1811-1822"xsd:string |
| http://purl.uniprot.org/citations/32658600 | http://purl.uniprot.org/core/title | "Circular RNA circ-LDLRAD3 serves as an oncogene to promote non-small cell lung cancer progression by upregulating SLC1A5 through sponging miR-137."xsd:string |
| http://purl.uniprot.org/citations/32658600 | http://purl.uniprot.org/core/volume | "17"xsd:string |
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