| http://purl.uniprot.org/citations/32661131 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32661131 | http://www.w3.org/2000/01/rdf-schema#comment | "The Arp2/3 complex regulates many cellular processes by stimulating formation of branched actin filament networks. Because three of its seven subunits exist as two different isoforms, mammals produce a family of Arp2/3 complexes with different properties that may be suited to different physiological contexts. To shed light on how isoform diversification affects Arp2/3 function, we determined a 4.2 Å resolution cryo-EM structure of the most active human Arp2/3 complex containing ARPC1B and ARPC5L, and compared it with the structure of the least active ARPC1A-ARPC5-containing complex. The architecture of each isoform-specific Arp2/3 complex is the same. Strikingly, however, the N-terminal half of ARPC5L is partially disordered compared to ARPC5, suggesting that this region of ARPC5/ARPC5L is an important determinant of complex activity. Confirming this idea, the nucleation activity of Arp2/3 complexes containing hybrid ARPC5/ARPC5L subunits is higher when the ARPC5L N-terminus is present, thereby providing insight into activity differences between the different Arp2/3 complexes."xsd:string |
| http://purl.uniprot.org/citations/32661131 | http://purl.org/dc/terms/identifier | "doi:10.1242/bio.054304"xsd:string |
| http://purl.uniprot.org/citations/32661131 | http://purl.uniprot.org/core/author | "Way M."xsd:string |
| http://purl.uniprot.org/citations/32661131 | http://purl.uniprot.org/core/author | "Cao L."xsd:string |
| http://purl.uniprot.org/citations/32661131 | http://purl.uniprot.org/core/author | "Kogata N."xsd:string |
| http://purl.uniprot.org/citations/32661131 | http://purl.uniprot.org/core/author | "Kjaer S."xsd:string |
| http://purl.uniprot.org/citations/32661131 | http://purl.uniprot.org/core/author | "von Loeffelholz O."xsd:string |
| http://purl.uniprot.org/citations/32661131 | http://purl.uniprot.org/core/author | "Moores C.A."xsd:string |
| http://purl.uniprot.org/citations/32661131 | http://purl.uniprot.org/core/author | "Purkiss A."xsd:string |
| http://purl.uniprot.org/citations/32661131 | http://purl.uniprot.org/core/author | "Romet-Lemonne G."xsd:string |
| http://purl.uniprot.org/citations/32661131 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32661131 | http://purl.uniprot.org/core/name | "Biol Open"xsd:string |
| http://purl.uniprot.org/citations/32661131 | http://purl.uniprot.org/core/pages | "bio054304"xsd:string |
| http://purl.uniprot.org/citations/32661131 | http://purl.uniprot.org/core/title | "Cryo-EM of human Arp2/3 complexes provides structural insights into actin nucleation modulation by ARPC5 isoforms."xsd:string |
| http://purl.uniprot.org/citations/32661131 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/32661131 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32661131 |
| http://purl.uniprot.org/citations/32661131 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32661131 |
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| http://purl.uniprot.org/uniprot/#_O15145-mappedCitation-32661131 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32661131 |
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| http://purl.uniprot.org/uniprot/#_P59998-mappedCitation-32661131 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32661131 |
| http://purl.uniprot.org/uniprot/#_P61158-mappedCitation-32661131 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32661131 |
| http://purl.uniprot.org/uniprot/#_P61160-mappedCitation-32661131 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32661131 |