| http://purl.uniprot.org/citations/32661276 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32661276 | http://www.w3.org/2000/01/rdf-schema#comment | "The DNA methyltransferases MET1 and CMT3 are known to be responsible for maintenance of DNA methylation at symmetric CG and CHG sites, respectively, in Arabidopsis thaliana. However, it is unknown how the expression of methyltransferase genes is regulated in different cell states and whether change in expression affects DNA methylation at the whole-genome level. Using a reverse genetic screen, we identified TCX5, a tesmin/TSO1-like CXC domain-containing protein, and demonstrated that it is a transcriptional repressor of genes required for maintenance of DNA methylation, which include MET1, CMT3, DDM1, KYP and VIMs. TCX5 functions redundantly with its paralogue TCX6 in repressing the expression of these genes. In the tcx5 tcx6 double mutant, expression of these genes is markedly increased, thereby leading to markedly increased DNA methylation at CHG sites and, to a lesser extent, at CG sites at the whole-genome level. Furthermore, our whole-genome DNA methylation analysis indicated that the CG and CHG methylation level is lower in differentiated quiescent cells than in dividing cells in the wild type but is comparable in the tcx5/6 mutant, suggesting that TCX5/6 are required for maintenance of the difference in DNA methylation between the two cell types. We identified TCX5/6-containing multi-subunit complexes, which are known as DREAM in other eukaryotes, and demonstrated that the Arabidopsis DREAM components function as a whole to preclude DNA hypermethylation. Given that the DREAM complexes are conserved from plants to animals, the preclusion of DNA hypermethylation by DREAM complexes may represent a conserved mechanism in eukaryotes."xsd:string |
| http://purl.uniprot.org/citations/32661276 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41477-020-0710-7"xsd:string |
| http://purl.uniprot.org/citations/32661276 | http://purl.uniprot.org/core/author | "Chen S."xsd:string |
| http://purl.uniprot.org/citations/32661276 | http://purl.uniprot.org/core/author | "Li L."xsd:string |
| http://purl.uniprot.org/citations/32661276 | http://purl.uniprot.org/core/author | "Liu N."xsd:string |
| http://purl.uniprot.org/citations/32661276 | http://purl.uniprot.org/core/author | "He X.J."xsd:string |
| http://purl.uniprot.org/citations/32661276 | http://purl.uniprot.org/core/author | "Ning Y.Q."xsd:string |
| http://purl.uniprot.org/citations/32661276 | http://purl.uniprot.org/core/author | "Su Y.N."xsd:string |
| http://purl.uniprot.org/citations/32661276 | http://purl.uniprot.org/core/author | "Lan K.K."xsd:string |
| http://purl.uniprot.org/citations/32661276 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32661276 | http://purl.uniprot.org/core/name | "Nat Plants"xsd:string |
| http://purl.uniprot.org/citations/32661276 | http://purl.uniprot.org/core/pages | "942-956"xsd:string |
| http://purl.uniprot.org/citations/32661276 | http://purl.uniprot.org/core/title | "DREAM complex suppresses DNA methylation maintenance genes and precludes DNA hypermethylation."xsd:string |
| http://purl.uniprot.org/citations/32661276 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/32661276 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32661276 |
| http://purl.uniprot.org/citations/32661276 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32661276 |
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