| http://purl.uniprot.org/citations/32667280 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32667280 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32667280 | http://www.w3.org/2000/01/rdf-schema#comment | "Identification of the full complement of genes in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a crucial step towards gaining a fuller understanding of its molecular biology. However, short and/or overlapping genes can be difficult to detect using conventional computational approaches, whereas high-throughput experimental approaches - such as ribosome profiling - cannot distinguish translation of functional peptides from regulatory translation or translational noise. By studying regions showing enhanced conservation at synonymous sites in alignments of SARS-CoV-2 and related viruses (subgenus Sarbecovirus) and correlating the results with the conserved presence of an open reading frame (ORF) and a plausible translation mechanism, a putative new gene - ORF3c - was identified. ORF3c overlaps ORF3a in an alternative reading frame. A recently published ribosome profiling study confirmed that ORF3c is indeed translated during infection. ORF3c is conserved across the subgenus Sarbecovirus, and encodes a 40-41 amino acid predicted transmembrane protein."xsd:string |
| http://purl.uniprot.org/citations/32667280 | http://purl.org/dc/terms/identifier | "doi:10.1099/jgv.0.001469"xsd:string |
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| http://purl.uniprot.org/citations/32667280 | http://purl.uniprot.org/core/author | "Firth A.E."xsd:string |
| http://purl.uniprot.org/citations/32667280 | http://purl.uniprot.org/core/author | "Firth A.E."xsd:string |
| http://purl.uniprot.org/citations/32667280 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32667280 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32667280 | http://purl.uniprot.org/core/name | "J. Gen. Virol."xsd:string |
| http://purl.uniprot.org/citations/32667280 | http://purl.uniprot.org/core/name | "J. Gen. Virol."xsd:string |
| http://purl.uniprot.org/citations/32667280 | http://purl.uniprot.org/core/pages | "1085-1089"xsd:string |
| http://purl.uniprot.org/citations/32667280 | http://purl.uniprot.org/core/pages | "1085-1089"xsd:string |
| http://purl.uniprot.org/citations/32667280 | http://purl.uniprot.org/core/title | "A putative new SARS-CoV protein, 3c, encoded in an ORF overlapping ORF3a."xsd:string |
| http://purl.uniprot.org/citations/32667280 | http://purl.uniprot.org/core/title | "A putative new SARS-CoV protein, 3c, encoded in an ORF overlapping ORF3a."xsd:string |
| http://purl.uniprot.org/citations/32667280 | http://purl.uniprot.org/core/volume | "101"xsd:string |
| http://purl.uniprot.org/citations/32667280 | http://purl.uniprot.org/core/volume | "101"xsd:string |
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