| http://purl.uniprot.org/citations/32668216 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32668216 | http://www.w3.org/2000/01/rdf-schema#comment | "Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the novel viral disease COVID-19. With no approved therapies, this pandemic illustrates the urgent need for broad-spectrum antiviral countermeasures against SARS-CoV-2 and future emerging CoVs. We report that remdesivir (RDV) potently inhibits SARS-CoV-2 replication in human lung cells and primary human airway epithelial cultures (EC50 = 0.01 μM). Weaker activity is observed in Vero E6 cells (EC50 = 1.65 μM) because of their low capacity to metabolize RDV. To rapidly evaluate in vivo efficacy, we engineered a chimeric SARS-CoV encoding the viral target of RDV, the RNA-dependent RNA polymerase of SARS-CoV-2. In mice infected with the chimeric virus, therapeutic RDV administration diminishes lung viral load and improves pulmonary function compared with vehicle-treated animals. These data demonstrate that RDV is potently active against SARS-CoV-2 in vitro and in vivo, supporting its further clinical testing for treatment of COVID-19."xsd:string |
| http://purl.uniprot.org/citations/32668216 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2020.107940"xsd:string |
| http://purl.uniprot.org/citations/32668216 | http://purl.uniprot.org/core/author | "Brown A.J."xsd:string |
| http://purl.uniprot.org/citations/32668216 | http://purl.uniprot.org/core/author | "Lu X."xsd:string |
| http://purl.uniprot.org/citations/32668216 | http://purl.uniprot.org/core/author | "Ma B."xsd:string |
| http://purl.uniprot.org/citations/32668216 | http://purl.uniprot.org/core/author | "Murakami E."xsd:string |
| http://purl.uniprot.org/citations/32668216 | http://purl.uniprot.org/core/author | "Schafer A."xsd:string |
| http://purl.uniprot.org/citations/32668216 | http://purl.uniprot.org/core/author | "Gully K."xsd:string |
| http://purl.uniprot.org/citations/32668216 | http://purl.uniprot.org/core/author | "Chappell J.D."xsd:string |
| http://purl.uniprot.org/citations/32668216 | http://purl.uniprot.org/core/author | "Baric R.S."xsd:string |
| http://purl.uniprot.org/citations/32668216 | http://purl.uniprot.org/core/author | "Leist S.R."xsd:string |
| http://purl.uniprot.org/citations/32668216 | http://purl.uniprot.org/core/author | "Martinez D.R."xsd:string |
| http://purl.uniprot.org/citations/32668216 | http://purl.uniprot.org/core/author | "Sheahan T.P."xsd:string |
| http://purl.uniprot.org/citations/32668216 | http://purl.uniprot.org/core/author | "Pruijssers A.J."xsd:string |
| http://purl.uniprot.org/citations/32668216 | http://purl.uniprot.org/core/author | "Agostini M.L."xsd:string |
| http://purl.uniprot.org/citations/32668216 | http://purl.uniprot.org/core/author | "Bilello J.P."xsd:string |
| http://purl.uniprot.org/citations/32668216 | http://purl.uniprot.org/core/author | "Cihlar T."xsd:string |
| http://purl.uniprot.org/citations/32668216 | http://purl.uniprot.org/core/author | "Denison M.R."xsd:string |
| http://purl.uniprot.org/citations/32668216 | http://purl.uniprot.org/core/author | "Feng J.Y."xsd:string |
| http://purl.uniprot.org/citations/32668216 | http://purl.uniprot.org/core/author | "Graham R.L."xsd:string |
| http://purl.uniprot.org/citations/32668216 | http://purl.uniprot.org/core/author | "Perry J.K."xsd:string |
| http://purl.uniprot.org/citations/32668216 | http://purl.uniprot.org/core/author | "Stevens L.J."xsd:string |
| http://purl.uniprot.org/citations/32668216 | http://purl.uniprot.org/core/author | "Pitts J."xsd:string |
| http://purl.uniprot.org/citations/32668216 | http://purl.uniprot.org/core/author | "Hughes T.M."xsd:string |