| http://purl.uniprot.org/citations/32668247 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32668247 | http://www.w3.org/2000/01/rdf-schema#comment | "Zinc finger protein St18 was initially reported as candidate tumor suppressor gene, and also suggested that fibroblast St18 positively regulates NF-κB activation. Despite the pleiotropic functions of St18, little is known about its roles in macrophages. Here, we report that myeloid St18 is a potent inhibitor of VEGF-A. Mice lacking St18 in myeloid lineages exhibit increased retinal vasculature with enhanced serum VEGF-A concentrations. Despite the normal activation of NF-κB target genes, these mice are highly susceptible to LPS-induced shock, polymicrobial sepsis, and experimental colitis, accompanied by enhanced vascular and intestinal leakage. Pharmacological inhibition of VEGF signaling rescued the high mortality rate of myeloid-specific St18-deficient mice in response to inflammation. Mechanistically, St18 directly binds to Sp1 and attenuates its activity, leading to the suppression of Sp1 target gene VEGF-A. Using mouse genetic and pharmacological models, we reveal myeloid St18 as a critical septic death protector."xsd:string |
| http://purl.uniprot.org/citations/32668247 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2020.107906"xsd:string |
| http://purl.uniprot.org/citations/32668247 | http://purl.uniprot.org/core/author | "Maruyama K."xsd:string |
| http://purl.uniprot.org/citations/32668247 | http://purl.uniprot.org/core/author | "Tanaka H."xsd:string |
| http://purl.uniprot.org/citations/32668247 | http://purl.uniprot.org/core/author | "Takayama Y."xsd:string |
| http://purl.uniprot.org/citations/32668247 | http://purl.uniprot.org/core/author | "Akira S."xsd:string |
| http://purl.uniprot.org/citations/32668247 | http://purl.uniprot.org/core/author | "Kondo T."xsd:string |
| http://purl.uniprot.org/citations/32668247 | http://purl.uniprot.org/core/author | "Takeuchi O."xsd:string |
| http://purl.uniprot.org/citations/32668247 | http://purl.uniprot.org/core/author | "Vandenbon A."xsd:string |
| http://purl.uniprot.org/citations/32668247 | http://purl.uniprot.org/core/author | "Takakura N."xsd:string |
| http://purl.uniprot.org/citations/32668247 | http://purl.uniprot.org/core/author | "Kidoya H."xsd:string |
| http://purl.uniprot.org/citations/32668247 | http://purl.uniprot.org/core/author | "Kumagai Y."xsd:string |
| http://purl.uniprot.org/citations/32668247 | http://purl.uniprot.org/core/author | "Martino M.M."xsd:string |
| http://purl.uniprot.org/citations/32668247 | http://purl.uniprot.org/core/author | "Sugisawa E."xsd:string |
| http://purl.uniprot.org/citations/32668247 | http://purl.uniprot.org/core/author | "Takemura N."xsd:string |
| http://purl.uniprot.org/citations/32668247 | http://purl.uniprot.org/core/author | "Eid M.M.A."xsd:string |
| http://purl.uniprot.org/citations/32668247 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32668247 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/32668247 | http://purl.uniprot.org/core/pages | "107906"xsd:string |
| http://purl.uniprot.org/citations/32668247 | http://purl.uniprot.org/core/title | "Zinc Finger Protein St18 Protects against Septic Death by Inhibiting VEGF-A from Macrophages."xsd:string |
| http://purl.uniprot.org/citations/32668247 | http://purl.uniprot.org/core/volume | "32"xsd:string |
| http://purl.uniprot.org/citations/32668247 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32668247 |
| http://purl.uniprot.org/citations/32668247 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32668247 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YXN3-mappedCitation-32668247 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32668247 |