| http://purl.uniprot.org/citations/32671696 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32671696 | http://www.w3.org/2000/01/rdf-schema#comment | "G9a is essential for dendritic plasticity and is associated with neurological disorders. The possible relationship between age-related hearing loss and G9a expression in the auditory cortex has not been fully explored. This study aimed to understand the expression patterns of G9a-mediated histone methylations in the auditory cortex during aging. Using immunofluorescence and western blotting, we demonstrated that a significant reduction in G9a expression observed in the auditory cortex of 24-month-old rats compared to 3-month-old rats, was associated with remarkable hearing threshold elevation and hair cell loss. Correspondingly, histone H3 lysine 9 (H3K9) mono- and dimethylation (marked by H3K9me1 and H3K9me2, respectively), which were regulated by G9a activity, also evidently decreased during aging. These findings, which merit further investigation, suggest a possible association between G9a-mediated histone methylations and central age-related hearing disorders."xsd:string |
| http://purl.uniprot.org/citations/32671696 | http://purl.org/dc/terms/identifier | "doi:10.1007/s12031-020-01663-z"xsd:string |
| http://purl.uniprot.org/citations/32671696 | http://purl.uniprot.org/core/author | "Li Q."xsd:string |
| http://purl.uniprot.org/citations/32671696 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/32671696 | http://purl.uniprot.org/core/author | "Wang M."xsd:string |
| http://purl.uniprot.org/citations/32671696 | http://purl.uniprot.org/core/author | "Xiang Y.H."xsd:string |
| http://purl.uniprot.org/citations/32671696 | http://purl.uniprot.org/core/author | "Bao X.M."xsd:string |
| http://purl.uniprot.org/citations/32671696 | http://purl.uniprot.org/core/author | "Liang X.J."xsd:string |
| http://purl.uniprot.org/citations/32671696 | http://purl.uniprot.org/core/author | "Zhu X.B."xsd:string |
| http://purl.uniprot.org/citations/32671696 | http://purl.uniprot.org/core/author | "Deng A.C."xsd:string |
| http://purl.uniprot.org/citations/32671696 | http://purl.uniprot.org/core/author | "Zhao P.P."xsd:string |
| http://purl.uniprot.org/citations/32671696 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/32671696 | http://purl.uniprot.org/core/name | "J Mol Neurosci"xsd:string |
| http://purl.uniprot.org/citations/32671696 | http://purl.uniprot.org/core/pages | "409-418"xsd:string |
| http://purl.uniprot.org/citations/32671696 | http://purl.uniprot.org/core/title | "Expression of G9a in Auditory Cortex Is Downregulated in a Rat Model of Age-Related Hearing Loss."xsd:string |
| http://purl.uniprot.org/citations/32671696 | http://purl.uniprot.org/core/volume | "71"xsd:string |
| http://purl.uniprot.org/citations/32671696 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32671696 |
| http://purl.uniprot.org/citations/32671696 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32671696 |
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| http://purl.uniprot.org/uniprot/#_A0A0G2JTA5-mappedCitation-32671696 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32671696 |
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| http://purl.uniprot.org/uniprot/#_A6KTN2-mappedCitation-32671696 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32671696 |
| http://purl.uniprot.org/uniprot/#_A6KTN3-mappedCitation-32671696 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32671696 |
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