| http://purl.uniprot.org/citations/32677026 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32677026 | http://www.w3.org/2000/01/rdf-schema#comment | "Secreted frizzled-related protein 4 (SFRP4) controls WNT signaling and is thought to play a role for tumor aggressiveness. Here, we analyzed a tissue microarray containing 11,152 prostate cancers with pathological, clinical and molecular data by immunohistochemistry. SFRP4 expression was higher in cancer than in non-neoplastic acinar cells. SFRP4 staining was seen in 64.9% of tumors and classified as weak in 33.2%, moderate in 23.9% and strong in 7.8% of cancers. SFRP4 overexpression was linked to advanced tumor stage, high classical/quantitative Gleason grade (p < 0.0001 each), lymph node metastasis (p = 0.0002), and a positive surgical margin (p = 0.0017). SFRP4 positivity was markedly more frequent in ERG positive (77.4%) than in ERG negative cancers (57.4% p < 0.0001). Subset analyses in 2725 cancers with and 3592 cancers without TMPRSS2:ERG fusion revealed that associations with tumor phenotype and patient outcome were largely driven by the subset of ERG negative tumors. In a multivariate analysis including various postoperative and prognostic clinico-pathological features, SFRP4 protein expression emerged as an independent prognostic parameter in ERG negative cancers. SFRP4 immunostaining was significantly linked with 10 of 11 previously analyzed chromosomal deletions (p < 0.05 each). In conclusion, high SFRP4 immunostaining is associated with poor prognosis and genomic instability in ERG negative prostate cancers."xsd:string |
| http://purl.uniprot.org/citations/32677026 | http://purl.org/dc/terms/identifier | "doi:10.1007/s12253-020-00861-9"xsd:string |
| http://purl.uniprot.org/citations/32677026 | http://purl.uniprot.org/core/author | "Simon R."xsd:string |
| http://purl.uniprot.org/citations/32677026 | http://purl.uniprot.org/core/author | "Lutz F."xsd:string |
| http://purl.uniprot.org/citations/32677026 | http://purl.uniprot.org/core/author | "Sauter G."xsd:string |
| http://purl.uniprot.org/citations/32677026 | http://purl.uniprot.org/core/author | "Haese A."xsd:string |
| http://purl.uniprot.org/citations/32677026 | http://purl.uniprot.org/core/author | "Dum D."xsd:string |
| http://purl.uniprot.org/citations/32677026 | http://purl.uniprot.org/core/author | "Bernreuther C."xsd:string |
| http://purl.uniprot.org/citations/32677026 | http://purl.uniprot.org/core/author | "Clauditz T.S."xsd:string |
| http://purl.uniprot.org/citations/32677026 | http://purl.uniprot.org/core/author | "Izbicki J.R."xsd:string |
| http://purl.uniprot.org/citations/32677026 | http://purl.uniprot.org/core/author | "Moller K."xsd:string |
| http://purl.uniprot.org/citations/32677026 | http://purl.uniprot.org/core/author | "Minner S."xsd:string |
| http://purl.uniprot.org/citations/32677026 | http://purl.uniprot.org/core/author | "Daghigh F."xsd:string |
| http://purl.uniprot.org/citations/32677026 | http://purl.uniprot.org/core/author | "Meiners J."xsd:string |
| http://purl.uniprot.org/citations/32677026 | http://purl.uniprot.org/core/author | "Lennartz M."xsd:string |
| http://purl.uniprot.org/citations/32677026 | http://purl.uniprot.org/core/author | "Steurer S."xsd:string |
| http://purl.uniprot.org/citations/32677026 | http://purl.uniprot.org/core/author | "Huland H."xsd:string |
| http://purl.uniprot.org/citations/32677026 | http://purl.uniprot.org/core/author | "Wittmer C."xsd:string |
| http://purl.uniprot.org/citations/32677026 | http://purl.uniprot.org/core/author | "Graefen M."xsd:string |
| http://purl.uniprot.org/citations/32677026 | http://purl.uniprot.org/core/author | "Schlomm T."xsd:string |
| http://purl.uniprot.org/citations/32677026 | http://purl.uniprot.org/core/author | "Burandt E."xsd:string |
| http://purl.uniprot.org/citations/32677026 | http://purl.uniprot.org/core/author | "Tsourlakis M.C."xsd:string |
| http://purl.uniprot.org/citations/32677026 | http://purl.uniprot.org/core/author | "Fraune C."xsd:string |
| http://purl.uniprot.org/citations/32677026 | http://purl.uniprot.org/core/author | "Heinzer H."xsd:string |