| http://purl.uniprot.org/citations/32679831 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32679831 | http://www.w3.org/2000/01/rdf-schema#comment | "Abnormal adipogenesis regulation is accompanied by a variety of metabolic dysfunctions and disorders. Caveolae play an important role in the regulation of fat production, modulated by caveolae-associated proteins (Cavin-1 to 4). Here, we investigated the role of Cavin-3 in lipogenesis and adipocyte differentiation, as the regulatory functions and roles of Cavin-3 in adipocytes are unknown. A Cavin-3 knockdown/overexpression stable cell line was established, and adipogenesis-related gene and protein expression changes were investigated by real-time quantitative PCR and Western blot analysis, respectively. Additionally, confocal immune-fluorescence microscopy was used to verify the intracellular position of the relevant factors. The results showed that Cavin-3 mRNA and protein expression were elevated, along with physiological factors such as lipid droplet formation, during adipogenesis. Cavin-3 silencing resulted in retarded adipocyte differentiation, and its overexpression accelerated this process. Furthermore, Cavin-3 knockdown resulted in decreased expression of adipogenesis-related genes, such as PPAR-γ, FAS, aP2, and Adipoq, whereas preadipocyte factor-1 (Pref-1) was markedly increased during adipocyte maturation. Overall, Cavin-3 influences caveolar stability and modulates the tumor necrosis factor-alpha-converting enzyme (TACE)-mediated Pref-1 shedding process in both mouse and human adipocytes. The Cavin-3-dependent shedding mechanism appears to be an important process in adipocyte maturation, providing a potential therapeutic target for obesity-related disorders."xsd:string |
| http://purl.uniprot.org/citations/32679831 | http://purl.org/dc/terms/identifier | "doi:10.3390/ijms21145000"xsd:string |
| http://purl.uniprot.org/citations/32679831 | http://purl.uniprot.org/core/author | "Kim S.T."xsd:string |
| http://purl.uniprot.org/citations/32679831 | http://purl.uniprot.org/core/author | "Park P.J."xsd:string |
| http://purl.uniprot.org/citations/32679831 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32679831 | http://purl.uniprot.org/core/name | "Int J Mol Sci"xsd:string |
| http://purl.uniprot.org/citations/32679831 | http://purl.uniprot.org/core/pages | "E5000"xsd:string |
| http://purl.uniprot.org/citations/32679831 | http://purl.uniprot.org/core/title | "Caveolae-Associated Protein 3 (Cavin-3) Influences Adipogenesis via TACE-Mediated Pref-1 Shedding."xsd:string |
| http://purl.uniprot.org/citations/32679831 | http://purl.uniprot.org/core/volume | "21"xsd:string |
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