| http://purl.uniprot.org/citations/32680882 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32680882 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32680882 | http://www.w3.org/2000/01/rdf-schema#comment | "Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the current coronavirus disease 2019 (COVID-19) pandemic. A major virulence factor of SARS-CoVs is the nonstructural protein 1 (Nsp1), which suppresses host gene expression by ribosome association. Here, we show that Nsp1 from SARS-CoV-2 binds to the 40S ribosomal subunit, resulting in shutdown of messenger RNA (mRNA) translation both in vitro and in cells. Structural analysis by cryo-electron microscopy of in vitro-reconstituted Nsp1-40S and various native Nsp1-40S and -80S complexes revealed that the Nsp1 C terminus binds to and obstructs the mRNA entry tunnel. Thereby, Nsp1 effectively blocks retinoic acid-inducible gene I-dependent innate immune responses that would otherwise facilitate clearance of the infection. Thus, the structural characterization of the inhibitory mechanism of Nsp1 may aid structure-based drug design against SARS-CoV-2."xsd:string |
| http://purl.uniprot.org/citations/32680882 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.abc8665"xsd:string |
| http://purl.uniprot.org/citations/32680882 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.abc8665"xsd:string |
| http://purl.uniprot.org/citations/32680882 | http://purl.uniprot.org/core/author | "Cheng J."xsd:string |
| http://purl.uniprot.org/citations/32680882 | http://purl.uniprot.org/core/author | "Cheng J."xsd:string |
| http://purl.uniprot.org/citations/32680882 | http://purl.uniprot.org/core/author | "Buschauer R."xsd:string |
| http://purl.uniprot.org/citations/32680882 | http://purl.uniprot.org/core/author | "Buschauer R."xsd:string |
| http://purl.uniprot.org/citations/32680882 | http://purl.uniprot.org/core/author | "Kirchhoff F."xsd:string |
| http://purl.uniprot.org/citations/32680882 | http://purl.uniprot.org/core/author | "Kirchhoff F."xsd:string |
| http://purl.uniprot.org/citations/32680882 | http://purl.uniprot.org/core/author | "Koepke L."xsd:string |
| http://purl.uniprot.org/citations/32680882 | http://purl.uniprot.org/core/author | "Koepke L."xsd:string |
| http://purl.uniprot.org/citations/32680882 | http://purl.uniprot.org/core/author | "Sparrer K.M.J."xsd:string |
| http://purl.uniprot.org/citations/32680882 | http://purl.uniprot.org/core/author | "Sparrer K.M.J."xsd:string |
| http://purl.uniprot.org/citations/32680882 | http://purl.uniprot.org/core/author | "Becker T."xsd:string |
| http://purl.uniprot.org/citations/32680882 | http://purl.uniprot.org/core/author | "Becker T."xsd:string |
| http://purl.uniprot.org/citations/32680882 | http://purl.uniprot.org/core/author | "Beckmann R."xsd:string |
| http://purl.uniprot.org/citations/32680882 | http://purl.uniprot.org/core/author | "Beckmann R."xsd:string |
| http://purl.uniprot.org/citations/32680882 | http://purl.uniprot.org/core/author | "Berninghausen O."xsd:string |
| http://purl.uniprot.org/citations/32680882 | http://purl.uniprot.org/core/author | "Berninghausen O."xsd:string |
| http://purl.uniprot.org/citations/32680882 | http://purl.uniprot.org/core/author | "Thoms M."xsd:string |
| http://purl.uniprot.org/citations/32680882 | http://purl.uniprot.org/core/author | "Thoms M."xsd:string |
| http://purl.uniprot.org/citations/32680882 | http://purl.uniprot.org/core/author | "Denk T."xsd:string |
| http://purl.uniprot.org/citations/32680882 | http://purl.uniprot.org/core/author | "Denk T."xsd:string |