| http://purl.uniprot.org/citations/32681364 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32681364 | http://www.w3.org/2000/01/rdf-schema#comment | "Introduction/objectivesOsteoarthritis (OA) ranks the most common joint disorder and the leading cause of disability. Growing evidence has revealed that OA has a strong genetic background, except for aging and obesity. The aim of this study is to determine the associations between potential functional variants of the GLIS3 and GLIS3-AS1 gene and risk of knee OA among a Chinese population.MethodsIn this case-control study with 810 knee OA cases and 900 healthy controls, seven selected functional SNPs of the GLIS3 and GLIS3-AS1 gene were evaluated.ResultsWe found minor alleles of rs10116772 (OR: 0.80, 95% CI: 0.69-0.92, P = 0.002), rs7045410 (OR: 0.74, 95% CI: 0.61-0.92, P = 0.005), and rs7032713 (OR: 0.76, 95% CI: 0.63-0.93, P = 0.006) were significantly associated with decreased risk of knee OA. Results of the dominant and recessive model, stratified analyses using Kellgren-Lawrence (KL) grading presented that the significant associations were not materially changed. Haplotype analysis indicated that haplotype CGT (OR: 0.66, 95% CI: 0.46-0.96, P = 0.031) and ATT (OR: 0.76, 95% CI: 0.6-0.95, P = 0.017) were significantly associated with decreased risk of knee OA. Further, they were also significantly associated with lower expression level of GLIS3, as well as higher expression level of GLIS3-AS1 in the articular cartilage specimens. Genotype-tissue expression (GTEX) data also validated that minor alleles of rs7045410 and rs7032713 were significantly associated with higher expression level of GLIS3-AS1 in thyroid and pituitary tissues (P < 0.001).ConclusionsThese findings revealed the essential role of genetic variants of the GLIS3 and GLIS3-AS1 gene in the occurrence of knee OA together. Key Point • Functional variants of the GLIS3 and GLIS3-AS1 gene were significantly associated with decreased risk of knee OA."xsd:string |
| http://purl.uniprot.org/citations/32681364 | http://purl.org/dc/terms/identifier | "doi:10.1007/s10067-019-04871-0"xsd:string |
| http://purl.uniprot.org/citations/32681364 | http://purl.uniprot.org/core/author | "Zhang B."xsd:string |
| http://purl.uniprot.org/citations/32681364 | http://purl.uniprot.org/core/author | "Zhang C.L."xsd:string |
| http://purl.uniprot.org/citations/32681364 | http://purl.uniprot.org/core/author | "Zhang J.L."xsd:string |
| http://purl.uniprot.org/citations/32681364 | http://purl.uniprot.org/core/author | "Yang H.T."xsd:string |
| http://purl.uniprot.org/citations/32681364 | http://purl.uniprot.org/core/author | "Zhou B.G."xsd:string |
| http://purl.uniprot.org/citations/32681364 | http://purl.uniprot.org/core/author | "Lei B.Y."xsd:string |
| http://purl.uniprot.org/citations/32681364 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/32681364 | http://purl.uniprot.org/core/name | "Clin Rheumatol"xsd:string |
| http://purl.uniprot.org/citations/32681364 | http://purl.uniprot.org/core/pages | "1039-1046"xsd:string |
| http://purl.uniprot.org/citations/32681364 | http://purl.uniprot.org/core/title | "Association study of the functional variants of the GLIS3 gene with risk of knee osteoarthritis."xsd:string |
| http://purl.uniprot.org/citations/32681364 | http://purl.uniprot.org/core/volume | "40"xsd:string |
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