| http://purl.uniprot.org/citations/32686190 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32686190 | http://www.w3.org/2000/01/rdf-schema#comment | "The catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) is a pleiotropic enzyme involved in DNA repair, cell cycle control, and transcription regulation. A potential role for DNA-PKcs in the regulation of osteoblastogenesis remains to be established. We show that pharmacological inhibition of DNA-PKcs kinase activity or gene silencing of Prkdc (encoding DNA-PKcs) in murine osteoblastic MC3T3-E1 cells and human adipose-derived mesenchymal stromal cells markedly enhanced osteogenesis and the expression of osteoblast differentiation marker genes. Inhibition of DNA-PKcs inhibited cell cycle progression and increased osteogenesis by significantly enhancing the bone morphogenetic protein 2 response in osteoblasts and other mesenchymal cell types. Importantly, in vivo pharmacological inhibition of the kinase enhanced bone biomechanical properties. Bones from osteoblast-specific conditional Prkdc-knockout mice exhibited a similar phenotype of increased stiffness. In conclusion, DNA-PKcs negatively regulates osteoblast differentiation, and therefore DNA-PKcs inhibitors may have therapeutic potential for bone regeneration and metabolic bone diseases."xsd:string |
| http://purl.uniprot.org/citations/32686190 | http://purl.org/dc/terms/identifier | "doi:10.1002/jcp.29927"xsd:string |
| http://purl.uniprot.org/citations/32686190 | http://purl.uniprot.org/core/author | "van Wijnen A.J."xsd:string |
| http://purl.uniprot.org/citations/32686190 | http://purl.uniprot.org/core/author | "Chung J.H."xsd:string |
| http://purl.uniprot.org/citations/32686190 | http://purl.uniprot.org/core/author | "St-Arnaud R."xsd:string |
| http://purl.uniprot.org/citations/32686190 | http://purl.uniprot.org/core/author | "Dudakovic A."xsd:string |
| http://purl.uniprot.org/citations/32686190 | http://purl.uniprot.org/core/author | "Farhat T."xsd:string |
| http://purl.uniprot.org/citations/32686190 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/32686190 | http://purl.uniprot.org/core/name | "J Cell Physiol"xsd:string |
| http://purl.uniprot.org/citations/32686190 | http://purl.uniprot.org/core/pages | "1195-1213"xsd:string |
| http://purl.uniprot.org/citations/32686190 | http://purl.uniprot.org/core/title | "Inhibition of the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) stimulates osteoblastogenesis by potentiating bone morphogenetic protein 2 (BMP2) responses."xsd:string |
| http://purl.uniprot.org/citations/32686190 | http://purl.uniprot.org/core/volume | "236"xsd:string |
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