| http://purl.uniprot.org/citations/32686865 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32686865 | http://www.w3.org/2000/01/rdf-schema#comment | "Alzheimer's disease (AD) is characterized by a chronic decline in cognitive function and is pathologically typified by cerebral deposition of amyloid-β peptide (Aβ). The production of Aβ is mediated by sequential proteolysis of amyloid precursor protein (APP) by β- and γ-secretases, and has been implicated as the essential determinant of AD pathology. Previous studies have demonstrated that the level of phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2] in the membrane may potentially modulate Aβ production. Given that PI(4,5)P2 is produced by type 1 phosphatidylinositol-4-phosphate 5-kinases (PIP5Ks), we sought to determine whether the level of PIP5K type Iα (PIP5K1A) can affect production of Aβ by modulating the lipid composition of the membrane. Using a HEK-derived cell line that constitutively expresses yellow fluorescent protein-tagged APP (APP-YFP), we demonstrated that overexpression of PIP5K1A results in significant enhancement of non-amyloidogenic APP processing and a concomitant suppression of the amyloidogenic pathway, leading to a marked decrease in secreted Aβ. Consistently, cells overexpressing PIP5K1A exhibited a significant redistribution of APP-YFP from endosomal compartments to the cell surface. Our findings suggest that PIP5K1A may play a critical role in governing Aβ production by modulating membrane distribution of APP, and as such, the pathway may be a valuable therapeutic target for AD."xsd:string |
| http://purl.uniprot.org/citations/32686865 | http://purl.org/dc/terms/identifier | "doi:10.1096/fj.202000113r"xsd:string |
| http://purl.uniprot.org/citations/32686865 | http://purl.uniprot.org/core/author | "Lee H."xsd:string |
| http://purl.uniprot.org/citations/32686865 | http://purl.uniprot.org/core/author | "Wu P.F."xsd:string |
| http://purl.uniprot.org/citations/32686865 | http://purl.uniprot.org/core/author | "Chen Y.W."xsd:string |
| http://purl.uniprot.org/citations/32686865 | http://purl.uniprot.org/core/author | "Wu P.Y."xsd:string |
| http://purl.uniprot.org/citations/32686865 | http://purl.uniprot.org/core/author | "Huang Y.S."xsd:string |
| http://purl.uniprot.org/citations/32686865 | http://purl.uniprot.org/core/author | "Lee Y.L."xsd:string |
| http://purl.uniprot.org/citations/32686865 | http://purl.uniprot.org/core/author | "Lu P.J."xsd:string |
| http://purl.uniprot.org/citations/32686865 | http://purl.uniprot.org/core/author | "Chou J.Y."xsd:string |
| http://purl.uniprot.org/citations/32686865 | http://purl.uniprot.org/core/author | "Liao Y.F."xsd:string |
| http://purl.uniprot.org/citations/32686865 | http://purl.uniprot.org/core/author | "Hsu W.M."xsd:string |
| http://purl.uniprot.org/citations/32686865 | http://purl.uniprot.org/core/author | "Bhore N."xsd:string |
| http://purl.uniprot.org/citations/32686865 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32686865 | http://purl.uniprot.org/core/name | "FASEB J"xsd:string |
| http://purl.uniprot.org/citations/32686865 | http://purl.uniprot.org/core/pages | "12127-12146"xsd:string |
| http://purl.uniprot.org/citations/32686865 | http://purl.uniprot.org/core/title | "Phosphatidylinositol-4-phosphate 5-kinase type 1alpha attenuates Abeta production by promoting non-amyloidogenic processing of amyloid precursor protein."xsd:string |
| http://purl.uniprot.org/citations/32686865 | http://purl.uniprot.org/core/volume | "34"xsd:string |
| http://purl.uniprot.org/citations/32686865 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32686865 |
| http://purl.uniprot.org/citations/32686865 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32686865 |
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| http://purl.uniprot.org/uniprot/#_A0A218KGR2-mappedCitation-32686865 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32686865 |