| http://purl.uniprot.org/citations/32690606 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32690606 | http://www.w3.org/2000/01/rdf-schema#comment | "Pancreas/duodenum homeobox protein 1 (PDX1) is an important transcription factor that regulates islet β-cell proliferation, differentiation, and function. Reduced expression of PDX1 is thought to contribute to β-cell loss and dysfunction in diabetes. Thus, promoting PDX1 expression can be an effective strategy to preserve β-cell mass and function. Previously, we established a PDX1 promoter-dependent luciferase system to screen agents that can promote PDX1 expression. Natural compound tectorigenin (TG) was identified as a promising candidate that could enhance the activity of the promoter for the PDX1 gene. In this study, we first demonstrated that TG could promote the expression of PDX1 in β-cells via activating extracellular signal-related kinase (ERK), as indicated by increased phosphorylation of ERK; this effect was observed under either normal or glucotoxic/lipotoxic conditions. We then found that TG could suppress induced apoptosis and improved the viability of β-cells under glucotoxicity and lipotoxicity by activation of ERK and reduction of reactive oxygen species and endoplasmic reticulum (ER) stress. These effects held true in vivo as well: prophylactic or therapeutic use of TG could obviously inhibit ER stress and decrease islet β-cell apoptosis in the pancreas of mice given a high-fat/high-sucrose diet (HFHSD), thus dramatically maintaining or restoring β-cell mass and islet size, respectively. Accordingly, both prophylactic and therapeutic use of TG improved HFHSD-impaired glucose metabolism in mice, as evidenced by ameliorating hyperglycemia and glucose intolerance. Taken together, TG, as an agent promoting PDX1 expression exhibits strong protective effects on islet β-cells both in vitro and in vivo."xsd:string |
| http://purl.uniprot.org/citations/32690606 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.ra120.012849"xsd:string |
| http://purl.uniprot.org/citations/32690606 | http://purl.uniprot.org/core/author | "Huang Y."xsd:string |
| http://purl.uniprot.org/citations/32690606 | http://purl.uniprot.org/core/author | "Li K."xsd:string |
| http://purl.uniprot.org/citations/32690606 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
| http://purl.uniprot.org/citations/32690606 | http://purl.uniprot.org/core/author | "Liang C."xsd:string |
| http://purl.uniprot.org/citations/32690606 | http://purl.uniprot.org/core/author | "Liu L."xsd:string |
| http://purl.uniprot.org/citations/32690606 | http://purl.uniprot.org/core/author | "Sun Y."xsd:string |
| http://purl.uniprot.org/citations/32690606 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/32690606 | http://purl.uniprot.org/core/author | "Sun L."xsd:string |
| http://purl.uniprot.org/citations/32690606 | http://purl.uniprot.org/core/author | "Wang G."xsd:string |
| http://purl.uniprot.org/citations/32690606 | http://purl.uniprot.org/core/author | "Wang S."xsd:string |
| http://purl.uniprot.org/citations/32690606 | http://purl.uniprot.org/core/author | "Zhou Z."xsd:string |
| http://purl.uniprot.org/citations/32690606 | http://purl.uniprot.org/core/author | "Yi J."xsd:string |
| http://purl.uniprot.org/citations/32690606 | http://purl.uniprot.org/core/author | "Yao X."xsd:string |
| http://purl.uniprot.org/citations/32690606 | http://purl.uniprot.org/core/author | "Yu C.L."xsd:string |
| http://purl.uniprot.org/citations/32690606 | http://purl.uniprot.org/core/author | "Bao Y.L."xsd:string |
| http://purl.uniprot.org/citations/32690606 | http://purl.uniprot.org/core/author | "Zheng L.H."xsd:string |
| http://purl.uniprot.org/citations/32690606 | http://purl.uniprot.org/core/author | "Song Z.B."xsd:string |
| http://purl.uniprot.org/citations/32690606 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32690606 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/32690606 | http://purl.uniprot.org/core/pages | "12975-12992"xsd:string |
| http://purl.uniprot.org/citations/32690606 | http://purl.uniprot.org/core/title | "Tectorigenin enhances PDX1 expression and protects pancreatic beta-cells by activating ERK and reducing ER stress."xsd:string |
| http://purl.uniprot.org/citations/32690606 | http://purl.uniprot.org/core/volume | "295"xsd:string |