| http://purl.uniprot.org/citations/32701359 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32701359 | http://www.w3.org/2000/01/rdf-schema#comment | "The long non-coding RNA (lncRNA) RUSC1-AS1 has been reported to be dysregulated in the progression of many cancers. Also, RUSC1-AS1 had been detected to be highly expressed in laryngeal squamous cell carcinoma and breast cancer cells, suggesting that RUSC1-AS1 may be a biomarker for cancers. However, the biological role and regulatory mechanism of RUSC1-AS1 in hepatocellular carcinoma (HCC) remain unknown. In this study, we found that RUSC1-AS1 was upregulated in HCC tissues and cells, and predicted unfavorable prognosis of HCC patients. The function assays including colony formation, EdU, TUNEL assay revealed that RUSC1-AS1 facilitated HCC cell proliferation and inhibited HCC cell apoptosis. Furthermore, mechanism assays including luciferase reporter assay and RIP assay demonstrated that RUSC1-AS1 could directly bind to hsa-miR-7-5p. Besides, hsa-miR-7-5p targeted and negatively regulated NOTCH3 expression. Moreover, RUSC1-AS1 sponged hsa-miR-7-5p to upregulate NOTCH3 and to trigger the NOTCH signaling pathway. The rescue assays depicted that RUSC1-AS1 regulated HCC cell proliferation and apoptosis through modulating NOTCH signaling. In conclusion, lncRNA RUSC1-AS1 promoted the proliferation and reduced the apoptosis of HCC cells through activation of NOTCH signaling via hsa-miR-7-5p/NOTCH3 axis."xsd:string |
| http://purl.uniprot.org/citations/32701359 | http://purl.org/dc/terms/identifier | "doi:10.4149/neo_2020_191010n1024"xsd:string |
| http://purl.uniprot.org/citations/32701359 | http://purl.uniprot.org/core/author | "Cheng L."xsd:string |
| http://purl.uniprot.org/citations/32701359 | http://purl.uniprot.org/core/author | "Peng L."xsd:string |
| http://purl.uniprot.org/citations/32701359 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/32701359 | http://purl.uniprot.org/core/author | "Chen Y.A."xsd:string |
| http://purl.uniprot.org/citations/32701359 | http://purl.uniprot.org/core/author | "Yang H.G."xsd:string |
| http://purl.uniprot.org/citations/32701359 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32701359 | http://purl.uniprot.org/core/name | "Neoplasma"xsd:string |
| http://purl.uniprot.org/citations/32701359 | http://purl.uniprot.org/core/pages | "1204-1213"xsd:string |
| http://purl.uniprot.org/citations/32701359 | http://purl.uniprot.org/core/title | "LncRNA RUSC1-AS1 promotes the proliferation of hepatocellular carcinoma cells through modulating NOTCH signaling."xsd:string |
| http://purl.uniprot.org/citations/32701359 | http://purl.uniprot.org/core/volume | "67"xsd:string |
| http://purl.uniprot.org/citations/32701359 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32701359 |
| http://purl.uniprot.org/citations/32701359 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32701359 |
| http://purl.uniprot.org/uniprot/#_A2RRG2-mappedCitation-32701359 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32701359 |
| http://purl.uniprot.org/uniprot/#_Q66K80-mappedCitation-32701359 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32701359 |
| http://purl.uniprot.org/uniprot/Q66K80 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/32701359 |
| http://purl.uniprot.org/uniprot/A2RRG2 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/32701359 |