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| http://purl.uniprot.org/citations/32705602 | http://www.w3.org/2000/01/rdf-schema#comment | "Comparative gene identification-58 (CGI-58), also known as α/β-hydrolase domain-containing 5 (ABHD5), is a member of a large family of proteins containing an α/β-hydrolase-fold. CGI-58 is well-known as the co-activator of adipose triglyceride lipase (ATGL), which is a key enzyme initiating cytosolic lipid droplet lipolysis. Mutations in either the human CGI-58 or ATGL gene cause an autosomal recessive neutral lipid storage disease, characterized by the excessive accumulation of triglyceride (TAG)-rich lipid droplets in the cytoplasm of almost all cell types. CGI-58, however, has ATGL-independent functions. Distinct phenotypes associated with CGI-58 deficiency commonly include ichthyosis (scaly dry skin), nonalcoholic steatohepatitis, and hepatic fibrosis. Through regulated interactions with multiple protein families, CGI-58 controls many metabolic and signaling pathways, such as lipid and glucose metabolism, energy balance, insulin signaling, inflammatory responses, and thermogenesis. Recent studies have shown that CGI-58 regulates the pathogenesis of common metabolic diseases in a tissue-specific manner. Future studies are needed to molecularly define ATGL-independent functions of CGI-58, including the newly identified serine protease activity of CGI-58. Elucidation of these versatile functions of CGI-58 may uncover fundamental cellular processes governing lipid and energy homeostasis, which may help develop novel approaches that counter against obesity and its associated metabolic sequelae."xsd:string |
| http://purl.uniprot.org/citations/32705602 | http://purl.org/dc/terms/identifier | "doi:10.1007/978-981-15-6082-8_13"xsd:string |
| http://purl.uniprot.org/citations/32705602 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
| http://purl.uniprot.org/citations/32705602 | http://purl.uniprot.org/core/author | "Wang H."xsd:string |
| http://purl.uniprot.org/citations/32705602 | http://purl.uniprot.org/core/author | "Yu L."xsd:string |
| http://purl.uniprot.org/citations/32705602 | http://purl.uniprot.org/core/author | "Grise A."xsd:string |
| http://purl.uniprot.org/citations/32705602 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32705602 | http://purl.uniprot.org/core/name | "Adv Exp Med Biol"xsd:string |
| http://purl.uniprot.org/citations/32705602 | http://purl.uniprot.org/core/pages | "197-222"xsd:string |
| http://purl.uniprot.org/citations/32705602 | http://purl.uniprot.org/core/title | "CGI-58: Versatile Regulator of Intracellular Lipid Droplet Homeostasis."xsd:string |
| http://purl.uniprot.org/citations/32705602 | http://purl.uniprot.org/core/volume | "1276"xsd:string |
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