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http://purl.uniprot.org/citations/32705992http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/32705992http://www.w3.org/2000/01/rdf-schema#comment"Congenital sensorineural hearing loss is related to mutations in numerous genes encoding the structures of the inner ear in majority of the cases. Mutations in GJB2 gene are the most frequently identified causes of congenital nonsyndromal hearing loss. GJB2 gene testing became a routine clinical tool. For GJB2-negative patients new genetic approaches including methods based on new generation sequencing give a chance to identify mutations in other genes. The frequent reason of mild-to-moderate hearing loss such as the deletions/mutations of the gene STRC encoding stereocilin protein were recognized (OMIM: 606440).

Objectives

To evaluate the audiological features in hearing impaired patients with deletions and point mutations in the STRC gene.

Patients and methods

The group of 28 patients from 21 unrelated families with pathological mutations in the STRC gene underwent audiological examination. The description and analysis of the results of full audiological examination was provided.

Results

All patients initially had bilateral nonsyndromal sensorineural hearing loss. Among 11 homozygotes of large deletion harboring STRC to CATSPER2 genes were 7 male individuals indicating the presence of male infertility syndrome. In general, 7 children failed audiological screening and 4 children underwent audiological assessment in the age of 3 and 6 months. The most frequently hearing thresholds were registered between 35 and 55 dB that corresponds to mild-to-moderate hearing impairment. The average age of diagnostics was 7.9 years (ranged from 3 months to 45 years). In the majority of patients the audiological profiles were flat or descending with elevation of thresholds at middle and high frequencies and relatively preserved thresholds at low frequencies. Hearing thresholds are symmetric and stable with age.

Conclusion

STRC-linked hearing loss is congenital, of mild and moderate severity. Special clinical and genetic approach for children who failed newborn hearing screening with mild-to-moderate hearing loss is necessary."xsd:string
http://purl.uniprot.org/citations/32705992http://purl.org/dc/terms/identifier"doi:10.1016/j.ijporl.2020.110247"xsd:string
http://purl.uniprot.org/citations/32705992http://purl.uniprot.org/core/author"Polyakov A.V."xsd:string
http://purl.uniprot.org/citations/32705992http://purl.uniprot.org/core/author"Markova T.G."xsd:string
http://purl.uniprot.org/citations/32705992http://purl.uniprot.org/core/author"Bliznetz E.A."xsd:string
http://purl.uniprot.org/citations/32705992http://purl.uniprot.org/core/author"Tavartkiladze G.A."xsd:string
http://purl.uniprot.org/citations/32705992http://purl.uniprot.org/core/author"Galeeva N.M."xsd:string
http://purl.uniprot.org/citations/32705992http://purl.uniprot.org/core/author"Lalayants M.R."xsd:string
http://purl.uniprot.org/citations/32705992http://purl.uniprot.org/core/author"Mironovich O.L."xsd:string
http://purl.uniprot.org/citations/32705992http://purl.uniprot.org/core/author"Alekseeva N.N."xsd:string
http://purl.uniprot.org/citations/32705992http://purl.uniprot.org/core/author"Chibisova S.S."xsd:string
http://purl.uniprot.org/citations/32705992http://purl.uniprot.org/core/date"2020"xsd:gYear
http://purl.uniprot.org/citations/32705992http://purl.uniprot.org/core/name"Int J Pediatr Otorhinolaryngol"xsd:string
http://purl.uniprot.org/citations/32705992http://purl.uniprot.org/core/pages"110247"xsd:string
http://purl.uniprot.org/citations/32705992http://purl.uniprot.org/core/title"Clinical features of hearing loss caused by STRC gene deletions/mutations in Russian population."xsd:string
http://purl.uniprot.org/citations/32705992http://purl.uniprot.org/core/volume"138"xsd:string
http://purl.uniprot.org/citations/32705992http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/32705992
http://purl.uniprot.org/citations/32705992http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/32705992
http://purl.uniprot.org/uniprot/#_A1L378-mappedCitation-32705992http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/32705992
http://purl.uniprot.org/uniprot/#_Q7RTU9-mappedCitation-32705992http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/32705992
http://purl.uniprot.org/uniprot/A1L378http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/32705992
http://purl.uniprot.org/uniprot/Q7RTU9http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/32705992