| http://purl.uniprot.org/citations/32710818 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32710818 | http://www.w3.org/2000/01/rdf-schema#comment | "Continuous neuronal survival is vital for mammals because mammalian brains have limited regeneration capability. After neurogenesis, suppression of apoptosis is needed to ensure a neuron's long-term survival. Here we describe a robust genetic program that intrinsically attenuates apoptosis competence in neurons. Developmental downregulation of the splicing regulator PTBP1 in immature neurons allows neural-specific splicing of the evolutionarily conserved Bak1 microexon 5. Exon 5 inclusion triggers nonsense-mediated mRNA decay (NMD) and unproductive translation of Bak1 transcripts (N-Bak mRNA), leading to suppression of pro-apoptotic BAK1 proteins and allowing neurons to reduce apoptosis. Germline heterozygous ablation of exon 5 increases BAK1 proteins exclusively in the brain, inflates neuronal apoptosis, and leads to early postnatal mortality. Therefore, neural-specific exon 5 splicing and depletion of BAK1 proteins uniquely repress neuronal apoptosis. Although apoptosis is important for development, attenuation of apoptosis competence through neural-specific splicing of the Bak1 microexon is essential for neuronal and animal survival."xsd:string |
| http://purl.uniprot.org/citations/32710818 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neuron.2020.06.036"xsd:string |
| http://purl.uniprot.org/citations/32710818 | http://purl.uniprot.org/core/author | "Chen L."xsd:string |
| http://purl.uniprot.org/citations/32710818 | http://purl.uniprot.org/core/author | "Lin L."xsd:string |
| http://purl.uniprot.org/citations/32710818 | http://purl.uniprot.org/core/author | "Zhang M."xsd:string |
| http://purl.uniprot.org/citations/32710818 | http://purl.uniprot.org/core/author | "Zheng S."xsd:string |
| http://purl.uniprot.org/citations/32710818 | http://purl.uniprot.org/core/author | "Stoilov P."xsd:string |
| http://purl.uniprot.org/citations/32710818 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32710818 | http://purl.uniprot.org/core/name | "Neuron"xsd:string |
| http://purl.uniprot.org/citations/32710818 | http://purl.uniprot.org/core/pages | "1180-1196.e8"xsd:string |
| http://purl.uniprot.org/citations/32710818 | http://purl.uniprot.org/core/title | "Developmental Attenuation of Neuronal Apoptosis by Neural-Specific Splicing of Bak1 Microexon."xsd:string |
| http://purl.uniprot.org/citations/32710818 | http://purl.uniprot.org/core/volume | "107"xsd:string |
| http://purl.uniprot.org/citations/32710818 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32710818 |
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| http://purl.uniprot.org/uniprot/#_A0A087WR33-mappedCitation-32710818 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32710818 |
| http://purl.uniprot.org/uniprot/#_E9Q0W3-mappedCitation-32710818 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32710818 |
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| http://purl.uniprot.org/uniprot/#_P70677-mappedCitation-32710818 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32710818 |
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| http://purl.uniprot.org/uniprot/#_A2A409-mappedCitation-32710818 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32710818 |
| http://purl.uniprot.org/uniprot/#_A2A412-mappedCitation-32710818 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32710818 |
| http://purl.uniprot.org/uniprot/#_F7CUQ1-mappedCitation-32710818 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32710818 |
| http://purl.uniprot.org/uniprot/#_A0A494BB74-mappedCitation-32710818 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32710818 |