| http://purl.uniprot.org/citations/32728200 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32728200 | http://www.w3.org/2000/01/rdf-schema#comment | "In cancer, myeloid cells have tumor-supporting roles. We reported that the protein GPNMB (glycoprotein nonmetastatic B) was profoundly upregulated in macrophages interacting with tumor cells. Here, using mouse tumor models, we show that macrophage-derived soluble GPNMB increases tumor growth and metastasis in Gpnmb-mutant mice (DBA/2J). GPNMB triggers in the cancer cells the formation of self-renewing spheroids, which are characterized by the expression of cancer stem cell markers, prolonged cell survival and increased tumor-forming ability. Through the CD44 receptor, GPNMB mechanistically activates tumor cells to express the cytokine IL-33 and its receptor IL-1R1L. We also determined that recombinant IL-33 binding to IL-1R1L is sufficient to induce tumor spheroid formation with features of cancer stem cells. Overall, our results reveal a new paracrine axis, GPNMB and IL-33, which is activated during the cross talk of macrophages with tumor cells and eventually promotes cancer cell survival, the expansion of cancer stem cells and the acquisition of a metastatic phenotype."xsd:string |
| http://purl.uniprot.org/citations/32728200 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41423-020-0501-0"xsd:string |
| http://purl.uniprot.org/citations/32728200 | http://purl.uniprot.org/core/author | "Borroni E.M."xsd:string |
| http://purl.uniprot.org/citations/32728200 | http://purl.uniprot.org/core/author | "Vacchini A."xsd:string |
| http://purl.uniprot.org/citations/32728200 | http://purl.uniprot.org/core/author | "Castagna A."xsd:string |
| http://purl.uniprot.org/citations/32728200 | http://purl.uniprot.org/core/author | "Allavena P."xsd:string |
| http://purl.uniprot.org/citations/32728200 | http://purl.uniprot.org/core/author | "Rimoldi V."xsd:string |
| http://purl.uniprot.org/citations/32728200 | http://purl.uniprot.org/core/author | "Erba E."xsd:string |
| http://purl.uniprot.org/citations/32728200 | http://purl.uniprot.org/core/author | "Panini N."xsd:string |
| http://purl.uniprot.org/citations/32728200 | http://purl.uniprot.org/core/author | "Liguori M."xsd:string |
| http://purl.uniprot.org/citations/32728200 | http://purl.uniprot.org/core/author | "Marchini S."xsd:string |
| http://purl.uniprot.org/citations/32728200 | http://purl.uniprot.org/core/author | "Tamborini M."xsd:string |
| http://purl.uniprot.org/citations/32728200 | http://purl.uniprot.org/core/author | "Belgiovine C."xsd:string |
| http://purl.uniprot.org/citations/32728200 | http://purl.uniprot.org/core/author | "Craparotta I."xsd:string |
| http://purl.uniprot.org/citations/32728200 | http://purl.uniprot.org/core/author | "Mannarino L."xsd:string |
| http://purl.uniprot.org/citations/32728200 | http://purl.uniprot.org/core/author | "Milanesi S."xsd:string |
| http://purl.uniprot.org/citations/32728200 | http://purl.uniprot.org/core/author | "Farina F.M."xsd:string |
| http://purl.uniprot.org/citations/32728200 | http://purl.uniprot.org/core/author | "Avigni R."xsd:string |
| http://purl.uniprot.org/citations/32728200 | http://purl.uniprot.org/core/author | "Colombo F.S."xsd:string |
| http://purl.uniprot.org/citations/32728200 | http://purl.uniprot.org/core/author | "Digifico E."xsd:string |
| http://purl.uniprot.org/citations/32728200 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/32728200 | http://purl.uniprot.org/core/name | "Cell Mol Immunol"xsd:string |
| http://purl.uniprot.org/citations/32728200 | http://purl.uniprot.org/core/pages | "711-722"xsd:string |
| http://purl.uniprot.org/citations/32728200 | http://purl.uniprot.org/core/title | "The soluble glycoprotein NMB (GPNMB) produced by macrophages induces cancer stemness and metastasis via CD44 and IL-33."xsd:string |