| http://purl.uniprot.org/citations/32734583 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32734583 | http://www.w3.org/2000/01/rdf-schema#comment | "OSBP-homologous proteins (ORPs, Oshp) are lipid binding/transfer proteins. Several ORP/Oshp localize to membrane contacts between the endoplasmic reticulum (ER) and the plasma membrane, where they mediate lipid transfer or regulate lipid-modifying enzymes. A common way in which they target contacts is by binding to the ER proteins, VAP/Scs2p, while the second membrane is targeted by other interactions with lipids or proteins.We have studied the cross-talk of secretory SNARE proteins and their regulators with ORP/Oshp and VAPA/Scs2p at ER-plasma membrane contact sites in yeast and murine primary neurons. We show that Oshp-Scs2p interactions depend on intact secretory SNARE proteins, especially Sec9p. SNAP-25/Sec9p directly interact with ORP/Osh proteins and their disruption destabilized the ORP/Osh proteins, associated with dysfunction of VAPA/Scs2p. Deleting OSH1-3 in yeast or knocking down ORP2 in primary neurons reduced the oligomerization of VAPA/Scs2p and affected their multiple interactions with SNAREs. These observations reveal a novel cross-talk between the machineries of ER-plasma membrane contact sites and those driving exocytosis."xsd:string |
| http://purl.uniprot.org/citations/32734583 | http://purl.org/dc/terms/identifier | "doi:10.1007/s00018-020-03604-w"xsd:string |
| http://purl.uniprot.org/citations/32734583 | http://purl.uniprot.org/core/author | "Shah S."xsd:string |
| http://purl.uniprot.org/citations/32734583 | http://purl.uniprot.org/core/author | "Olkkonen V.M."xsd:string |
| http://purl.uniprot.org/citations/32734583 | http://purl.uniprot.org/core/author | "Rosenmund C."xsd:string |
| http://purl.uniprot.org/citations/32734583 | http://purl.uniprot.org/core/author | "Jantti J."xsd:string |
| http://purl.uniprot.org/citations/32734583 | http://purl.uniprot.org/core/author | "Weber-Boyvat M."xsd:string |
| http://purl.uniprot.org/citations/32734583 | http://purl.uniprot.org/core/author | "Trimbuch T."xsd:string |
| http://purl.uniprot.org/citations/32734583 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/32734583 | http://purl.uniprot.org/core/name | "Cell Mol Life Sci"xsd:string |
| http://purl.uniprot.org/citations/32734583 | http://purl.uniprot.org/core/pages | "1689-1708"xsd:string |
| http://purl.uniprot.org/citations/32734583 | http://purl.uniprot.org/core/title | "ORP/Osh mediate cross-talk between ER-plasma membrane contact site components and plasma membrane SNAREs."xsd:string |
| http://purl.uniprot.org/citations/32734583 | http://purl.uniprot.org/core/volume | "78"xsd:string |
| http://purl.uniprot.org/citations/32734583 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32734583 |
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