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http://purl.uniprot.org/citations/32735900http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/32735900http://www.w3.org/2000/01/rdf-schema#comment"Based on genome-scale loss-of-function screens we discovered that Topoisomerase III-β (TOP3B), a human topoisomerase that acts on DNA and RNA, is required for yellow fever virus and dengue virus-2 replication. Remarkably, we found that TOP3B is required for efficient replication of all positive-sense-single stranded RNA viruses tested, including SARS-CoV-2. While there are no drugs that specifically inhibit this topoisomerase, we posit that TOP3B is an attractive anti-viral target."xsd:string
http://purl.uniprot.org/citations/32735900http://purl.org/dc/terms/identifier"doi:10.1016/j.antiviral.2020.104874"xsd:string
http://purl.uniprot.org/citations/32735900http://purl.uniprot.org/core/author"Bedford M.T."xsd:string
http://purl.uniprot.org/citations/32735900http://purl.uniprot.org/core/author"Xie X."xsd:string
http://purl.uniprot.org/citations/32735900http://purl.uniprot.org/core/author"Hirano M."xsd:string
http://purl.uniprot.org/citations/32735900http://purl.uniprot.org/core/author"Bukreyev A."xsd:string
http://purl.uniprot.org/citations/32735900http://purl.uniprot.org/core/author"Rajsbaum R."xsd:string
http://purl.uniprot.org/citations/32735900http://purl.uniprot.org/core/author"Bradrick S.S."xsd:string
http://purl.uniprot.org/citations/32735900http://purl.uniprot.org/core/author"Garcia-Blanco M.A."xsd:string
http://purl.uniprot.org/citations/32735900http://purl.uniprot.org/core/author"Shi P.Y."xsd:string
http://purl.uniprot.org/citations/32735900http://purl.uniprot.org/core/author"Shan C."xsd:string
http://purl.uniprot.org/citations/32735900http://purl.uniprot.org/core/author"Hage A."xsd:string
http://purl.uniprot.org/citations/32735900http://purl.uniprot.org/core/author"Fagg W.S."xsd:string
http://purl.uniprot.org/citations/32735900http://purl.uniprot.org/core/author"Prasanth K.R."xsd:string
http://purl.uniprot.org/citations/32735900http://purl.uniprot.org/core/author"McAnarney E.T."xsd:string
http://purl.uniprot.org/citations/32735900http://purl.uniprot.org/core/author"Menachery V."xsd:string
http://purl.uniprot.org/citations/32735900http://purl.uniprot.org/core/author"Pietzsch C.A."xsd:string
http://purl.uniprot.org/citations/32735900http://purl.uniprot.org/core/date"2020"xsd:gYear
http://purl.uniprot.org/citations/32735900http://purl.uniprot.org/core/name"Antiviral Res"xsd:string
http://purl.uniprot.org/citations/32735900http://purl.uniprot.org/core/pages"104874"xsd:string
http://purl.uniprot.org/citations/32735900http://purl.uniprot.org/core/title"Topoisomerase III-beta is required for efficient replication of positive-sense RNA viruses."xsd:string
http://purl.uniprot.org/citations/32735900http://purl.uniprot.org/core/volume"182"xsd:string
http://purl.uniprot.org/citations/32735900http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/32735900
http://purl.uniprot.org/citations/32735900http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/32735900