| http://purl.uniprot.org/citations/32736066 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32736066 | http://www.w3.org/2000/01/rdf-schema#comment | "Cyclin E is a key factor for S phase entry, and deregulation of Cyclin E results in developmental defects and tumors. Therefore, proper cycling of Cyclin E is crucial for normal growth. Here we found that transcription factors Apontic (Apt) and E2f1 cooperate to induce cyclin E in Drosophila. Functional binding motifs of Apt and E2f1 are clustered in the first intron of Drosophila cyclin E and directly contribute to the cyclin E transcription. Knockout of apt and e2f1 together abolished Cyclin E expression. Furthermore, Apt up-regulates Retinoblastoma family protein 1 (Rbf1) for proper chromatin compaction, which is known to repress cyclin E. Notably, Apt-dependent up-regulation of Cyclin E and Rbf1 is evolutionarily conserved in mammalian cells. Our findings reveal a unique mechanism underlying the induction and subsequent decline of Cyclin E expression."xsd:string |
| http://purl.uniprot.org/citations/32736066 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.isci.2020.101369"xsd:string |
| http://purl.uniprot.org/citations/32736066 | http://purl.uniprot.org/core/author | "Shen Y."xsd:string |
| http://purl.uniprot.org/citations/32736066 | http://purl.uniprot.org/core/author | "Hirose S."xsd:string |
| http://purl.uniprot.org/citations/32736066 | http://purl.uniprot.org/core/author | "Suzuki E."xsd:string |
| http://purl.uniprot.org/citations/32736066 | http://purl.uniprot.org/core/author | "Wang X.F."xsd:string |
| http://purl.uniprot.org/citations/32736066 | http://purl.uniprot.org/core/author | "Liu J.X."xsd:string |
| http://purl.uniprot.org/citations/32736066 | http://purl.uniprot.org/core/author | "Ma Z.Y."xsd:string |
| http://purl.uniprot.org/citations/32736066 | http://purl.uniprot.org/core/author | "Zhou Z.Z."xsd:string |
| http://purl.uniprot.org/citations/32736066 | http://purl.uniprot.org/core/author | "Liu Q.X."xsd:string |
| http://purl.uniprot.org/citations/32736066 | http://purl.uniprot.org/core/author | "Zhang H.R."xsd:string |
| http://purl.uniprot.org/citations/32736066 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32736066 | http://purl.uniprot.org/core/name | "iScience"xsd:string |
| http://purl.uniprot.org/citations/32736066 | http://purl.uniprot.org/core/pages | "101369"xsd:string |
| http://purl.uniprot.org/citations/32736066 | http://purl.uniprot.org/core/title | "Evolutionarily Conserved Roles for Apontic in Induction and Subsequent Decline of Cyclin E Expression."xsd:string |
| http://purl.uniprot.org/citations/32736066 | http://purl.uniprot.org/core/volume | "23"xsd:string |
| http://purl.uniprot.org/citations/32736066 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32736066 |
| http://purl.uniprot.org/citations/32736066 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32736066 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KEQ0-mappedCitation-32736066 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32736066 |
| http://purl.uniprot.org/uniprot/#_A0A0B4LHG1-mappedCitation-32736066 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32736066 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KGD0-mappedCitation-32736066 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32736066 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KGM3-mappedCitation-32736066 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32736066 |
| http://purl.uniprot.org/uniprot/#_A1Z9A8-mappedCitation-32736066 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32736066 |
| http://purl.uniprot.org/uniprot/#_A4V0R4-mappedCitation-32736066 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32736066 |