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http://purl.uniprot.org/citations/32738025http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/32738025http://www.w3.org/2000/01/rdf-schema#comment"

Background

Metastatic cutaneous squamous cell carcinoma (cSCC) carries a poor prognosis. Increased numbers of CD8+ cytotoxic T cells are associated with a favorable prognosis and programmed cell death receptor-1 is a suppressor of the CD8+ cytotoxic T cell response. We aim to define their expression in metastatic cutaneous squamous cell carcinoma.

Methods

Cytotoxic T cell infiltrates and tumoral PD-L1 expression in lymph node metastases from patients with cSCC of the head and neck were analyzed.

Results

High tumoral PD-L1 expression, intratumoral and peritumoral CD8+ cell density in metastases were significantly associated with poor primary tumor differentiation. Low PD-L1 expression, intratumoral and peritumoral CD8+ density were associated with lower grade primary tumor differentiation. Low PD-L1 expression correlated with disease progression.

Conclusions

Increased expression of PD-L1 correlates with increased CD8+ cell density. Increased expression of PD-L1 in poorly differentiated tumors may be more likely to benefit from anti PD-1/PD-L1 therapy."xsd:string
http://purl.uniprot.org/citations/32738025http://purl.org/dc/terms/identifier"doi:10.1002/hed.26370"xsd:string
http://purl.uniprot.org/citations/32738025http://purl.uniprot.org/core/author"Lin D.T."xsd:string
http://purl.uniprot.org/citations/32738025http://purl.uniprot.org/core/author"Kraft S."xsd:string
http://purl.uniprot.org/citations/32738025http://purl.uniprot.org/core/author"Hoang M.P."xsd:string
http://purl.uniprot.org/citations/32738025http://purl.uniprot.org/core/author"Deschler D.G."xsd:string
http://purl.uniprot.org/citations/32738025http://purl.uniprot.org/core/author"Emerick K.S."xsd:string
http://purl.uniprot.org/citations/32738025http://purl.uniprot.org/core/author"Gadkaree S.K."xsd:string
http://purl.uniprot.org/citations/32738025http://purl.uniprot.org/core/date"2020"xsd:gYear
http://purl.uniprot.org/citations/32738025http://purl.uniprot.org/core/name"Head Neck"xsd:string
http://purl.uniprot.org/citations/32738025http://purl.uniprot.org/core/pages"3226-3234"xsd:string
http://purl.uniprot.org/citations/32738025http://purl.uniprot.org/core/title"Programmed cell death ligand-1 and cytotoxic T cell infiltrates in metastatic cutaneous squamous cell carcinoma of the head and neck."xsd:string
http://purl.uniprot.org/citations/32738025http://purl.uniprot.org/core/volume"42"xsd:string
http://purl.uniprot.org/citations/32738025http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/32738025
http://purl.uniprot.org/citations/32738025http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/32738025
http://purl.uniprot.org/uniprot/#_Q0GN75-mappedCitation-32738025http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/32738025
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http://purl.uniprot.org/uniprot/Q0GN75http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/32738025
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