| http://purl.uniprot.org/citations/32738332 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32738332 | http://www.w3.org/2000/01/rdf-schema#comment | "The role of nuclear factor erythroid 2-related factor 2 (Nrf2) in bile acid (BA) homeostasis remains controversial. In this study, activation of Nrf2 was achieved either pharmacologically by CDDO-imidazolide (CDDO-Im) or genetically through a "gene dose-response" model consisting of Nrf2-null, wild-type (WT), Keap1-knockdown (Keap1-KD), and Keap1-hepatocyte knockout (Keap1-HKO) mice. In WT mice, CDDO-Im increased bile flow and decreased hepatic BAs, which was associated with a down-regulation of the canalicular BA efflux transporter Bsep and an increase in biliary BA excretion. In contrast, hepatic Bsep and biliary BA excretion were not altered in Keap1-KD or Keap1-HKO mice, suggesting that Nrf2 is not important for regulating Bsep or BA-dependent bile flow. In contrast, hepatic Mrp2 and Mrp3 were up-regulated by both pharmacological and genetic activations of Nrf2. Furthermore, ileal BA transporters (Asbt and Ostβ) and cholesterol transporters (Abcg5 and Abcg8) were down-regulated by both pharmacological and genetic activations of Nrf2, suggesting a role of Nrf2 in intestinal absorption of BAs and cholesterol. In Nrf2-null mice, CDDO-Im down-regulated hepatic BA uptake transporters (Ntcp, Oatp1a1, and Oatp1b2), leading to a 39-fold increase of serum BAs. To conclude, the present study demonstrates that activation of Nrf2 in mice up-regulates Mrp2 and Mrp3 in the liver and down-regulates BA and cholesterol transporters in the intestine."xsd:string |
| http://purl.uniprot.org/citations/32738332 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.taap.2020.115170"xsd:string |
| http://purl.uniprot.org/citations/32738332 | http://purl.uniprot.org/core/author | "Liu J."xsd:string |
| http://purl.uniprot.org/citations/32738332 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/32738332 | http://purl.uniprot.org/core/author | "Klaassen C.D."xsd:string |
| http://purl.uniprot.org/citations/32738332 | http://purl.uniprot.org/core/author | "Lickteig A.J."xsd:string |
| http://purl.uniprot.org/citations/32738332 | http://purl.uniprot.org/core/author | "Csanaky I.L."xsd:string |
| http://purl.uniprot.org/citations/32738332 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32738332 | http://purl.uniprot.org/core/name | "Toxicol Appl Pharmacol"xsd:string |
| http://purl.uniprot.org/citations/32738332 | http://purl.uniprot.org/core/pages | "115170"xsd:string |
| http://purl.uniprot.org/citations/32738332 | http://purl.uniprot.org/core/title | "Effects of ablation and activation of Nrf2 on bile acid homeostasis in male mice."xsd:string |
| http://purl.uniprot.org/citations/32738332 | http://purl.uniprot.org/core/volume | "403"xsd:string |
| http://purl.uniprot.org/citations/32738332 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32738332 |
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