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| http://purl.uniprot.org/citations/32767706 | http://www.w3.org/2000/01/rdf-schema#comment | "Ferritinophagy is a form of selective autophagy responsible for degrading intracellular ferritin, mediated by nuclear receptor coactivator 4 (NCOA4). NCOA4 plays significant roles in systemic iron homeostasis, and its disruption leads to simultaneous anemia and susceptibility to iron overload. The importance of iron colorectal cancer pathogenesis is well studied; however, the role of ferritinophagy in colon cancer cell growth has not been assessed. Disruption of ferritinophagy via NCOA4 knockout leads to only marginal differences in growth under basal and iron-restricted conditions. Moreover, NCOA4 played no significant role in cell death induced by 5-fluorouracil and erastin. Western blotting analysis for ferritin and transferrin receptor 1 found a dose-dependent effect on expression in both proteins in wild-type and NCOA4 knockout cell lines, but further investigation revealed no difference in growth response when treated at both high and low doses. Our data demonstrate a marginal role for ferritinophagy in growth both under normal and cytotoxic conditions in colon cancer cells, as well as a possible compensatory mechanism in colon cancer cells in response to ferroptosis induction."xsd:string |
| http://purl.uniprot.org/citations/32767706 | http://purl.org/dc/terms/identifier | "doi:10.1002/cbin.11439"xsd:string |
| http://purl.uniprot.org/citations/32767706 | http://purl.uniprot.org/core/author | "Hasan M."xsd:string |
| http://purl.uniprot.org/citations/32767706 | http://purl.uniprot.org/core/author | "Reddy S.M."xsd:string |
| http://purl.uniprot.org/citations/32767706 | http://purl.uniprot.org/core/author | "Das N.K."xsd:string |
| http://purl.uniprot.org/citations/32767706 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32767706 | http://purl.uniprot.org/core/name | "Cell Biol Int"xsd:string |
| http://purl.uniprot.org/citations/32767706 | http://purl.uniprot.org/core/pages | "2307-2314"xsd:string |
| http://purl.uniprot.org/citations/32767706 | http://purl.uniprot.org/core/title | "Ferritinophagy is not required for colon cancer cell growth."xsd:string |
| http://purl.uniprot.org/citations/32767706 | http://purl.uniprot.org/core/volume | "44"xsd:string |
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