| http://purl.uniprot.org/citations/32773035 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32773035 | http://www.w3.org/2000/01/rdf-schema#comment | "The UPF3B-dependent branch of the nonsense-mediated RNA decay (NMD) pathway is critical for human cognition. Here, we examined the role of UPF3B in the olfactory system. Single-cell RNA-sequencing (scRNA-seq) analysis demonstrated considerable heterogeneity of olfactory sensory neuron (OSN) cell populations in wild-type (WT) mice, and revealed that UPF3B loss influences specific subsets of these cell populations. UPF3B also regulates the expression of a large cadre of antimicrobial genes in OSNs, and promotes the selection of specific olfactory receptor (Olfr) genes for expression in mature OSNs (mOSNs). RNA-seq and Ribotag analyses identified classes of mRNAs expressed and translated at different levels in WT and Upf3b-null mOSNs. Integrating multiple computational approaches, UPF3B-dependent NMD target transcripts that are candidates to mediate the functions of NMD in mOSNs were identified in vivo. Together, our data provides a valuable resource for the olfactory field and insights into the roles of NMD in vivo."xsd:string |
| http://purl.uniprot.org/citations/32773035 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.57525"xsd:string |
| http://purl.uniprot.org/citations/32773035 | http://purl.uniprot.org/core/author | "Chen S."xsd:string |
| http://purl.uniprot.org/citations/32773035 | http://purl.uniprot.org/core/author | "Tan K."xsd:string |
| http://purl.uniprot.org/citations/32773035 | http://purl.uniprot.org/core/author | "Zhang L."xsd:string |
| http://purl.uniprot.org/citations/32773035 | http://purl.uniprot.org/core/author | "Zhang K."xsd:string |
| http://purl.uniprot.org/citations/32773035 | http://purl.uniprot.org/core/author | "Wilkinson M.F."xsd:string |
| http://purl.uniprot.org/citations/32773035 | http://purl.uniprot.org/core/author | "Shum E.Y."xsd:string |
| http://purl.uniprot.org/citations/32773035 | http://purl.uniprot.org/core/author | "Gallo R.L."xsd:string |
| http://purl.uniprot.org/citations/32773035 | http://purl.uniprot.org/core/author | "Jones S.H."xsd:string |
| http://purl.uniprot.org/citations/32773035 | http://purl.uniprot.org/core/author | "Sohni A."xsd:string |
| http://purl.uniprot.org/citations/32773035 | http://purl.uniprot.org/core/author | "Lake B.B."xsd:string |
| http://purl.uniprot.org/citations/32773035 | http://purl.uniprot.org/core/author | "Pandya S."xsd:string |
| http://purl.uniprot.org/citations/32773035 | http://purl.uniprot.org/core/author | "Cook-Andersen H."xsd:string |
| http://purl.uniprot.org/citations/32773035 | http://purl.uniprot.org/core/author | "Chousal J.N."xsd:string |
| http://purl.uniprot.org/citations/32773035 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32773035 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
| http://purl.uniprot.org/citations/32773035 | http://purl.uniprot.org/core/pages | "e57525"xsd:string |
| http://purl.uniprot.org/citations/32773035 | http://purl.uniprot.org/core/title | "The role of the NMD factor UPF3B in olfactory sensory neurons."xsd:string |
| http://purl.uniprot.org/citations/32773035 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/32773035 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32773035 |
| http://purl.uniprot.org/citations/32773035 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32773035 |
| http://purl.uniprot.org/uniprot/#_A2RT14-mappedCitation-32773035 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32773035 |
| http://purl.uniprot.org/uniprot/#_Q149I6-mappedCitation-32773035 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32773035 |