| http://purl.uniprot.org/citations/32777727 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32777727 | http://www.w3.org/2000/01/rdf-schema#comment | "Kaposi's sarcoma (KS) tends to occur in injured or inflamed sites of the body, which is described as the "Koebner phenomenon". KS is also unique in its extraordinary angio-hyperplastic inflammatory phenotype. Recently, evidence has accrued indicating that KS may derive from KSHV-infected mesenchymal stem cells (MSCs), which possess enhanced migration and homing ability. Inspired by these findings, we hypothesized that KS may arise from KSHV-infected MSCs that chemotactically migrate to preexisting inflammatory or injured sites. Here we report that KSHV infection of human MSCs significantly up-regulated expression of several chemokine receptors and enhanced cell migration ability in vitro. Furthermore, using a wound mouse model, we demonstrated that KSHV infection dramatically promotes MSCs migrating and settling in the wound sites. In addition, two mice in the KSHV-infected group showed purpura and tumors with KS-like features. Taken together, KSHV-enhanced MSC migration ability and inflammatory microenvironment play crucial roles in KS development."xsd:string |
| http://purl.uniprot.org/citations/32777727 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.virol.2020.07.012"xsd:string |
| http://purl.uniprot.org/citations/32777727 | http://purl.uniprot.org/core/author | "Chen W."xsd:string |
| http://purl.uniprot.org/citations/32777727 | http://purl.uniprot.org/core/author | "Wang X."xsd:string |
| http://purl.uniprot.org/citations/32777727 | http://purl.uniprot.org/core/author | "Yuan Y."xsd:string |
| http://purl.uniprot.org/citations/32777727 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32777727 | http://purl.uniprot.org/core/name | "Virology"xsd:string |
| http://purl.uniprot.org/citations/32777727 | http://purl.uniprot.org/core/pages | "5-12"xsd:string |
| http://purl.uniprot.org/citations/32777727 | http://purl.uniprot.org/core/title | "KSHV enhances mesenchymal stem cell homing and promotes KS-like pathogenesis."xsd:string |
| http://purl.uniprot.org/citations/32777727 | http://purl.uniprot.org/core/volume | "549"xsd:string |
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