| http://purl.uniprot.org/citations/32778760 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32778760 | http://www.w3.org/2000/01/rdf-schema#comment | "Chronic inflammation is a common feature of obesity, with elevated cytokines such as interleukin-1 (IL-1) in the circulation and tissues. Here, we report an unconventional IL-1R-MyD88-IRAK2-PHB/OPA1 signaling axis that reprograms mitochondrial metabolism in adipocytes to exacerbate obesity. IL-1 induced recruitment of IRAK2 Myddosome to mitochondria outer membranes via recognition by TOM20, followed by TIMM50-guided translocation of IRAK2 into mitochondria inner membranes, to suppress oxidative phosphorylation and fatty acid oxidation, thereby attenuating energy expenditure. Adipocyte-specific MyD88 or IRAK2 deficiency reduced high-fat-diet-induced weight gain, increased energy expenditure and ameliorated insulin resistance, associated with a smaller adipocyte size and increased cristae formation. IRAK2 kinase inactivation also reduced high-fat diet-induced metabolic diseases. Mechanistically, IRAK2 suppressed respiratory super-complex formation via interaction with PHB1 and OPA1 upon stimulation of IL-1. Taken together, our results suggest that the IRAK2 Myddosome functions as a critical link between inflammation and metabolism, representing a novel therapeutic target for patients with obesity."xsd:string |
| http://purl.uniprot.org/citations/32778760 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41590-020-0750-1"xsd:string |
| http://purl.uniprot.org/citations/32778760 | http://purl.uniprot.org/core/author | "Gao J."xsd:string |
| http://purl.uniprot.org/citations/32778760 | http://purl.uniprot.org/core/author | "Li X."xsd:string |
| http://purl.uniprot.org/citations/32778760 | http://purl.uniprot.org/core/author | "Liu W."xsd:string |
| http://purl.uniprot.org/citations/32778760 | http://purl.uniprot.org/core/author | "Qian W."xsd:string |
| http://purl.uniprot.org/citations/32778760 | http://purl.uniprot.org/core/author | "Zhou H."xsd:string |
| http://purl.uniprot.org/citations/32778760 | http://purl.uniprot.org/core/author | "Yang H."xsd:string |
| http://purl.uniprot.org/citations/32778760 | http://purl.uniprot.org/core/author | "Yin M."xsd:string |
| http://purl.uniprot.org/citations/32778760 | http://purl.uniprot.org/core/author | "Wang H."xsd:string |
| http://purl.uniprot.org/citations/32778760 | http://purl.uniprot.org/core/author | "Zhao J."xsd:string |
| http://purl.uniprot.org/citations/32778760 | http://purl.uniprot.org/core/author | "Yu M."xsd:string |
| http://purl.uniprot.org/citations/32778760 | http://purl.uniprot.org/core/author | "Brown J.M."xsd:string |
| http://purl.uniprot.org/citations/32778760 | http://purl.uniprot.org/core/author | "Smith J.D."xsd:string |
| http://purl.uniprot.org/citations/32778760 | http://purl.uniprot.org/core/author | "Dent R."xsd:string |
| http://purl.uniprot.org/citations/32778760 | http://purl.uniprot.org/core/author | "Chen Y.R."xsd:string |
| http://purl.uniprot.org/citations/32778760 | http://purl.uniprot.org/core/author | "Tang F."xsd:string |
| http://purl.uniprot.org/citations/32778760 | http://purl.uniprot.org/core/author | "Fox P.L."xsd:string |
| http://purl.uniprot.org/citations/32778760 | http://purl.uniprot.org/core/author | "Hine C."xsd:string |
| http://purl.uniprot.org/citations/32778760 | http://purl.uniprot.org/core/author | "Drazba J.A."xsd:string |
| http://purl.uniprot.org/citations/32778760 | http://purl.uniprot.org/core/author | "Carman J.A."xsd:string |
| http://purl.uniprot.org/citations/32778760 | http://purl.uniprot.org/core/author | "Dongre A."xsd:string |
| http://purl.uniprot.org/citations/32778760 | http://purl.uniprot.org/core/author | "Schugar R.C."xsd:string |
| http://purl.uniprot.org/citations/32778760 | http://purl.uniprot.org/core/author | "McDowell R.E."xsd:string |