| http://purl.uniprot.org/citations/32780743 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32780743 | http://www.w3.org/2000/01/rdf-schema#comment | "Long-term memory (LTM) formation depends on the conversed cAMP response element-binding protein (CREB)-dependent gene transcription followed by de novo protein synthesis. Thirsty fruit flies can be trained to associate an odor with water reward to form water-reward LTM (wLTM), which can last for over 24 hours without a significant decline. The role of de novo protein synthesis and CREB-regulated gene expression changes in neural circuits that contribute to wLTM remains unclear. Here, we show that acute inhibition of protein synthesis in the mushroom body (MB) αβ or γ neurons during memory formation using a cold-sensitive ribosome-inactivating toxin disrupts wLTM. Furthermore, adult stage-specific expression of dCREB2b in αβ or γ neurons also disrupts wLTM. The MB αβ and γ neurons can be further classified into five different neuronal subsets including αβ core, αβ surface, αβ posterior, γ main, and γ dorsal. We observed that the neurotransmission from αβ surface and γ dorsal neuron subsets is required for wLTM retrieval, whereas the αβ core, αβ posterior, and γ main are dispensable. Adult stage-specific expression of dCREB2b in αβ surface and γ dorsal neurons inhibits wLTM formation. In vivo calcium imaging revealed that αβ surface and γ dorsal neurons form wLTM traces with different dynamic properties, and these memory traces are abolished by dCREB2b expression. Our results suggest that a small population of neurons within the MB circuits support long-term storage of water-reward memory in Drosophila."xsd:string |
| http://purl.uniprot.org/citations/32780743 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pgen.1008963"xsd:string |
| http://purl.uniprot.org/citations/32780743 | http://purl.uniprot.org/core/author | "Wu T."xsd:string |
| http://purl.uniprot.org/citations/32780743 | http://purl.uniprot.org/core/author | "Lee J.Y."xsd:string |
| http://purl.uniprot.org/citations/32780743 | http://purl.uniprot.org/core/author | "Tsai Y.L."xsd:string |
| http://purl.uniprot.org/citations/32780743 | http://purl.uniprot.org/core/author | "Chiang H.C."xsd:string |
| http://purl.uniprot.org/citations/32780743 | http://purl.uniprot.org/core/author | "Chang L.Y."xsd:string |
| http://purl.uniprot.org/citations/32780743 | http://purl.uniprot.org/core/author | "Wu C.L."xsd:string |
| http://purl.uniprot.org/citations/32780743 | http://purl.uniprot.org/core/author | "Lee W.P."xsd:string |
| http://purl.uniprot.org/citations/32780743 | http://purl.uniprot.org/core/author | "Fu T.F."xsd:string |
| http://purl.uniprot.org/citations/32780743 | http://purl.uniprot.org/core/author | "Chiu T.H."xsd:string |
| http://purl.uniprot.org/citations/32780743 | http://purl.uniprot.org/core/author | "Chiang M.H."xsd:string |
| http://purl.uniprot.org/citations/32780743 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32780743 | http://purl.uniprot.org/core/name | "PLoS Genet"xsd:string |
| http://purl.uniprot.org/citations/32780743 | http://purl.uniprot.org/core/pages | "e1008963"xsd:string |
| http://purl.uniprot.org/citations/32780743 | http://purl.uniprot.org/core/title | "Mushroom body subsets encode CREB2-dependent water-reward long-term memory in Drosophila."xsd:string |
| http://purl.uniprot.org/citations/32780743 | http://purl.uniprot.org/core/volume | "16"xsd:string |
| http://purl.uniprot.org/citations/32780743 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32780743 |
| http://purl.uniprot.org/citations/32780743 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32780743 |
| http://purl.uniprot.org/uniprot/#_A0A1Z1CK36-mappedCitation-32780743 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32780743 |
| http://purl.uniprot.org/uniprot/#_C6SUU1-mappedCitation-32780743 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32780743 |
| http://purl.uniprot.org/uniprot/#_M9PHW9-mappedCitation-32780743 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32780743 |
| http://purl.uniprot.org/uniprot/#_M9PHZ6-mappedCitation-32780743 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32780743 |
| http://purl.uniprot.org/uniprot/#_Q9VWW0-mappedCitation-32780743 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32780743 |