| http://purl.uniprot.org/citations/32783949 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32783949 | http://www.w3.org/2000/01/rdf-schema#comment | "Plasma cells secreting affinity-matured antibodies develop in germinal centers (GCs), where B cells migrate persistently and directionally over defined periods of time. How modes of GC B cell migration influence plasma cell development remained unclear. Through genetic deletion of the F-actin bundling protein Swiprosin-1/EF-hand domain family member 2 (EFhd2) and by two-photon microscopy, we show that EFhd2 restrains B cell speed in GCs and hapten-specific plasma cell output. Modeling the GC reaction reveals that increasing GC B cell speed promotes plasma cell generation. Lack of EFhd2 also reduces contacts of GC B cells with follicular dendritic cells in vivo. Computational modeling uncovers that both GC output and antibody affinity depend quantitatively on contacts of GC B cells with follicular dendritic cells when B cells migrate more persistently. Collectively, our data explain how GC B cells integrate speed and persistence of cell migration with B cell receptor affinity."xsd:string |
| http://purl.uniprot.org/citations/32783949 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2020.108030"xsd:string |
| http://purl.uniprot.org/citations/32783949 | http://purl.uniprot.org/core/author | "Thomas J."xsd:string |
| http://purl.uniprot.org/citations/32783949 | http://purl.uniprot.org/core/author | "Tripal P."xsd:string |
| http://purl.uniprot.org/citations/32783949 | http://purl.uniprot.org/core/author | "Reimer D."xsd:string |
| http://purl.uniprot.org/citations/32783949 | http://purl.uniprot.org/core/author | "Mielenz D."xsd:string |
| http://purl.uniprot.org/citations/32783949 | http://purl.uniprot.org/core/author | "Boettcher M."xsd:string |
| http://purl.uniprot.org/citations/32783949 | http://purl.uniprot.org/core/author | "Mougiakakos D."xsd:string |
| http://purl.uniprot.org/citations/32783949 | http://purl.uniprot.org/core/author | "Schulz S.R."xsd:string |
| http://purl.uniprot.org/citations/32783949 | http://purl.uniprot.org/core/author | "Steinmetz T."xsd:string |
| http://purl.uniprot.org/citations/32783949 | http://purl.uniprot.org/core/author | "Hauser A.E."xsd:string |
| http://purl.uniprot.org/citations/32783949 | http://purl.uniprot.org/core/author | "Meyer-Hermann M."xsd:string |
| http://purl.uniprot.org/citations/32783949 | http://purl.uniprot.org/core/author | "Niesner R.A."xsd:string |
| http://purl.uniprot.org/citations/32783949 | http://purl.uniprot.org/core/author | "Urbanczyk S."xsd:string |
| http://purl.uniprot.org/citations/32783949 | http://purl.uniprot.org/core/author | "Rakhymzhan A."xsd:string |
| http://purl.uniprot.org/citations/32783949 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32783949 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/32783949 | http://purl.uniprot.org/core/pages | "108030"xsd:string |
| http://purl.uniprot.org/citations/32783949 | http://purl.uniprot.org/core/title | "B Cell Speed and B-FDC Contacts in Germinal Centers Determine Plasma Cell Output via Swiprosin-1/EFhd2."xsd:string |
| http://purl.uniprot.org/citations/32783949 | http://purl.uniprot.org/core/volume | "32"xsd:string |
| http://purl.uniprot.org/citations/32783949 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32783949 |
| http://purl.uniprot.org/citations/32783949 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32783949 |
| http://purl.uniprot.org/uniprot/#_I7CPP0-mappedCitation-32783949 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32783949 |
| http://purl.uniprot.org/uniprot/#_Q60636-mappedCitation-32783949 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32783949 |