| http://purl.uniprot.org/citations/32787108 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32787108 | http://www.w3.org/2000/01/rdf-schema#comment | "Proline-rich antimicrobial peptides (PrAMPs) are promising lead compounds for developing new antimicrobials; however, their narrow spectrum of action is limiting. PrAMPs kill bacteria binding to their ribosomes and inhibiting protein synthesis. In this study, 133 derivatives of the PrAMP Bac7(1-16) were synthesized to identify the crucial residues for ribosome inactivation and antimicrobial activity. Then, five new Bac7(1-16) derivatives were conceived and characterized by antibacterial and membrane permeabilization assays, X-ray crystallography, and molecular dynamics simulations. Some derivatives displayed broad spectrum activity, encompassing Escherichia coli, Klebsiella pneumoniae, Acinetobacter baumanii, Pseudomonas aeruginosa, and Staphylococcus aureus. Two peptides out of five acquired a weak membrane-perturbing activity while maintaining the ability to inhibit protein synthesis. These derivatives became independent of the SbmA transporter, commonly used by native PrAMPs, suggesting that they obtained a novel route to enter bacterial cells. PrAMP-derived compounds could become new-generation antimicrobials to combat antibiotic-resistant pathogens."xsd:string |
| http://purl.uniprot.org/citations/32787108 | http://purl.org/dc/terms/identifier | "doi:10.1021/acs.jmedchem.0c00665"xsd:string |
| http://purl.uniprot.org/citations/32787108 | http://purl.uniprot.org/core/author | "Beckert B."xsd:string |
| http://purl.uniprot.org/citations/32787108 | http://purl.uniprot.org/core/author | "Wilson D.N."xsd:string |
| http://purl.uniprot.org/citations/32787108 | http://purl.uniprot.org/core/author | "Mardirossian M."xsd:string |
| http://purl.uniprot.org/citations/32787108 | http://purl.uniprot.org/core/author | "Scocchi M."xsd:string |
| http://purl.uniprot.org/citations/32787108 | http://purl.uniprot.org/core/author | "Polikanov Y.S."xsd:string |
| http://purl.uniprot.org/citations/32787108 | http://purl.uniprot.org/core/author | "Valencic E."xsd:string |
| http://purl.uniprot.org/citations/32787108 | http://purl.uniprot.org/core/author | "Hilpert K."xsd:string |
| http://purl.uniprot.org/citations/32787108 | http://purl.uniprot.org/core/author | "Armas F."xsd:string |
| http://purl.uniprot.org/citations/32787108 | http://purl.uniprot.org/core/author | "Magistrato A."xsd:string |
| http://purl.uniprot.org/citations/32787108 | http://purl.uniprot.org/core/author | "Borisek J."xsd:string |
| http://purl.uniprot.org/citations/32787108 | http://purl.uniprot.org/core/author | "Buchmann J."xsd:string |
| http://purl.uniprot.org/citations/32787108 | http://purl.uniprot.org/core/author | "Sola R."xsd:string |
| http://purl.uniprot.org/citations/32787108 | http://purl.uniprot.org/core/author | "Syroegin E.A."xsd:string |
| http://purl.uniprot.org/citations/32787108 | http://purl.uniprot.org/core/author | "Collis D.W.P."xsd:string |
| http://purl.uniprot.org/citations/32787108 | http://purl.uniprot.org/core/author | "Di Stasi A."xsd:string |
| http://purl.uniprot.org/citations/32787108 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32787108 | http://purl.uniprot.org/core/name | "J Med Chem"xsd:string |
| http://purl.uniprot.org/citations/32787108 | http://purl.uniprot.org/core/pages | "9590-9602"xsd:string |
| http://purl.uniprot.org/citations/32787108 | http://purl.uniprot.org/core/title | "Peptide Inhibitors of Bacterial Protein Synthesis with Broad Spectrum and SbmA-Independent Bactericidal Activity against Clinical Pathogens."xsd:string |
| http://purl.uniprot.org/citations/32787108 | http://purl.uniprot.org/core/volume | "63"xsd:string |
| http://purl.uniprot.org/citations/32787108 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32787108 |
| http://purl.uniprot.org/citations/32787108 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32787108 |