| http://purl.uniprot.org/citations/32794417 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32794417 | http://www.w3.org/2000/01/rdf-schema#comment | "Oropharyngeal squamous cell carcinoma (OPSCC) is subclassified by the World Health Organization into two different entities: human papillomavirus (HPV)-positive and HPV-negative tumors. HPV infection promotes the epithelial-to-mesenchymal transition (EMT) and transformation of keratinocyte stem cells into cancer stem cells. EMT is a crucial process in the carcinogenesis of epithelial-derived malignancies, and we aimed to study the role of its markers in OPSCC. This study consists of 202 consecutive OPSCC patients diagnosed and treated with curative intent. We examined E-cadherin, β-catenin, and vimentin expression using immunohistochemistry and compared these with tumor and patient characteristics and treatment outcome. We found that the cell-membranous expression of β-catenin was stronger in HPV-positive than in HPV-negative tumors, and it was stronger in the presence of regional metastasis. The stromal vimentin expression was stronger among HPV-positive tumors. A high E-cadherin expression was associated with tumor grade. No relationship between these markers and survival emerged. In conclusion, β-catenin and vimentin seem to play different roles in OPSCC: the former in the tumor tissue itself, and the latter in the tumor stroma. HPV infection may exploit the β-catenin and vimentin pathways in carcinogenic process. More, β-catenin may serve as a marker for the occurrence of regional metastasis."xsd:string |
| http://purl.uniprot.org/citations/32794417 | http://purl.org/dc/terms/identifier | "doi:10.1369/0022155420950841"xsd:string |
| http://purl.uniprot.org/citations/32794417 | http://purl.uniprot.org/core/author | "Haglund C."xsd:string |
| http://purl.uniprot.org/citations/32794417 | http://purl.uniprot.org/core/author | "Hagstrom J."xsd:string |
| http://purl.uniprot.org/citations/32794417 | http://purl.uniprot.org/core/author | "Mohamed H."xsd:string |
| http://purl.uniprot.org/citations/32794417 | http://purl.uniprot.org/core/author | "Atula T."xsd:string |
| http://purl.uniprot.org/citations/32794417 | http://purl.uniprot.org/core/author | "Makitie A."xsd:string |
| http://purl.uniprot.org/citations/32794417 | http://purl.uniprot.org/core/author | "Jouhi L."xsd:string |
| http://purl.uniprot.org/citations/32794417 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32794417 | http://purl.uniprot.org/core/name | "J Histochem Cytochem"xsd:string |
| http://purl.uniprot.org/citations/32794417 | http://purl.uniprot.org/core/pages | "595-606"xsd:string |
| http://purl.uniprot.org/citations/32794417 | http://purl.uniprot.org/core/title | "Expression and Role of E-Cadherin, beta-Catenin, and Vimentin in Human Papillomavirus-Positive and Human Papillomavirus-Negative Oropharyngeal Squamous Cell Carcinoma."xsd:string |
| http://purl.uniprot.org/citations/32794417 | http://purl.uniprot.org/core/volume | "68"xsd:string |
| http://purl.uniprot.org/citations/32794417 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32794417 |
| http://purl.uniprot.org/citations/32794417 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/32794417 |
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| http://purl.uniprot.org/uniprot/#_A0A0U2ZQU7-mappedCitation-32794417 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32794417 |
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| http://purl.uniprot.org/uniprot/#_B0YJC4-mappedCitation-32794417 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/32794417 |