| http://purl.uniprot.org/citations/32807988 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32807988 | http://www.w3.org/2000/01/rdf-schema#comment | "The identification of prostate stem/progenitor cells and characterization of the prostate epithelial cell lineage hierarchy are critical for understanding prostate cancer initiation. Here, we characterized 35,129 cells from mouse prostates, and identified a unique luminal cell type (termed type C luminal cell (Luminal-C)) marked by Tacstd2, Ck4 and Psca expression. Luminal-C cells located at the distal prostate invagination tips (termed Dist-Luminal-C) exhibited greater capacity for organoid formation in vitro and prostate epithelial duct regeneration in vivo. Lineage tracing of Luminal-C cells indicated that Dist-Luminal-C cells reconstituted distal prostate luminal lineages through self-renewal and differentiation. Deletion of Pten in Dist-Luminal-C cells resulted in prostatic intraepithelial neoplasia. We further characterized 11,374 human prostate cells and confirmed the existence of h-Luminal-C cells. Our study provides insights into the prostate lineage hierarchy, identifies Dist-Luminal-C cells as the luminal progenitor cell population in invagination tips and suggests one of the potential cellular origins of prostate cancer."xsd:string |
| http://purl.uniprot.org/citations/32807988 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41588-020-0642-1"xsd:string |
| http://purl.uniprot.org/citations/32807988 | http://purl.uniprot.org/core/author | "Chen L."xsd:string |
| http://purl.uniprot.org/citations/32807988 | http://purl.uniprot.org/core/author | "Gao D."xsd:string |
| http://purl.uniprot.org/citations/32807988 | http://purl.uniprot.org/core/author | "Chen Y."xsd:string |
| http://purl.uniprot.org/citations/32807988 | http://purl.uniprot.org/core/author | "He J."xsd:string |
| http://purl.uniprot.org/citations/32807988 | http://purl.uniprot.org/core/author | "Han M."xsd:string |
| http://purl.uniprot.org/citations/32807988 | http://purl.uniprot.org/core/author | "Li C."xsd:string |
| http://purl.uniprot.org/citations/32807988 | http://purl.uniprot.org/core/author | "Li F."xsd:string |
| http://purl.uniprot.org/citations/32807988 | http://purl.uniprot.org/core/author | "Li L."xsd:string |
| http://purl.uniprot.org/citations/32807988 | http://purl.uniprot.org/core/author | "Liu Z."xsd:string |
| http://purl.uniprot.org/citations/32807988 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
| http://purl.uniprot.org/citations/32807988 | http://purl.uniprot.org/core/author | "Guo W."xsd:string |
| http://purl.uniprot.org/citations/32807988 | http://purl.uniprot.org/core/author | "Wei Y."xsd:string |
| http://purl.uniprot.org/citations/32807988 | http://purl.uniprot.org/core/author | "Zhang X."xsd:string |
| http://purl.uniprot.org/citations/32807988 | http://purl.uniprot.org/core/author | "Wei H."xsd:string |
| http://purl.uniprot.org/citations/32807988 | http://purl.uniprot.org/core/author | "Zhu Y."xsd:string |
| http://purl.uniprot.org/citations/32807988 | http://purl.uniprot.org/core/author | "Dai H."xsd:string |
| http://purl.uniprot.org/citations/32807988 | http://purl.uniprot.org/core/author | "Xia X."xsd:string |
| http://purl.uniprot.org/citations/32807988 | http://purl.uniprot.org/core/author | "Aji R."xsd:string |
| http://purl.uniprot.org/citations/32807988 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32807988 | http://purl.uniprot.org/core/name | "Nat Genet"xsd:string |
| http://purl.uniprot.org/citations/32807988 | http://purl.uniprot.org/core/pages | "908-918"xsd:string |
| http://purl.uniprot.org/citations/32807988 | http://purl.uniprot.org/core/title | "Single-cell transcriptomics identifies a distinct luminal progenitor cell type in distal prostate invagination tips."xsd:string |