| http://purl.uniprot.org/citations/32812867 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32812867 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32812867 | http://www.w3.org/2000/01/rdf-schema#comment | "Translation of mitochondrial messenger RNA (mt-mRNA) is performed by distinct mitoribosomes comprising at least 36 mitochondria-specific proteins. How these mitoribosomal proteins assist in the binding of mt-mRNA and to what extent they are involved in the translocation of transfer RNA (mt-tRNA) is unclear. To visualize the process of translation in human mitochondria, we report ~3.0 Å resolution structure of the human mitoribosome, including the L7/L12 stalk, and eight structures of its functional complexes with mt-mRNA, mt-tRNAs, recycling factor and additional trans factors. The study reveals a transacting protein module LRPPRC-SLIRP that delivers mt-mRNA to the mitoribosomal small subunit through a dedicated platform formed by the mitochondria-specific protein mS39. Mitoribosomal proteins of the large subunit mL40, mL48, and mL64 coordinate translocation of mt-tRNA. The comparison between those structures shows dynamic interactions between the mitoribosome and its ligands, suggesting a sequential mechanism of conformational changes."xsd:string |
| http://purl.uniprot.org/citations/32812867 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.58362"xsd:string |
| http://purl.uniprot.org/citations/32812867 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.58362"xsd:string |
| http://purl.uniprot.org/citations/32812867 | http://purl.uniprot.org/core/author | "Aibara S."xsd:string |
| http://purl.uniprot.org/citations/32812867 | http://purl.uniprot.org/core/author | "Aibara S."xsd:string |
| http://purl.uniprot.org/citations/32812867 | http://purl.uniprot.org/core/author | "Singh V."xsd:string |
| http://purl.uniprot.org/citations/32812867 | http://purl.uniprot.org/core/author | "Singh V."xsd:string |
| http://purl.uniprot.org/citations/32812867 | http://purl.uniprot.org/core/author | "Amunts A."xsd:string |
| http://purl.uniprot.org/citations/32812867 | http://purl.uniprot.org/core/author | "Amunts A."xsd:string |
| http://purl.uniprot.org/citations/32812867 | http://purl.uniprot.org/core/author | "Modelska A."xsd:string |
| http://purl.uniprot.org/citations/32812867 | http://purl.uniprot.org/core/author | "Modelska A."xsd:string |
| http://purl.uniprot.org/citations/32812867 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32812867 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32812867 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
| http://purl.uniprot.org/citations/32812867 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
| http://purl.uniprot.org/citations/32812867 | http://purl.uniprot.org/core/pages | "e58362"xsd:string |
| http://purl.uniprot.org/citations/32812867 | http://purl.uniprot.org/core/pages | "e58362"xsd:string |
| http://purl.uniprot.org/citations/32812867 | http://purl.uniprot.org/core/title | "Structural basis of mitochondrial translation. ."xsd:string |
| http://purl.uniprot.org/citations/32812867 | http://purl.uniprot.org/core/title | "Structural basis of mitochondrial translation."xsd:string |
| http://purl.uniprot.org/citations/32812867 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/32812867 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/32812867 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32812867 |
| http://purl.uniprot.org/citations/32812867 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32812867 |