| http://purl.uniprot.org/citations/32818430 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/32818430 | http://www.w3.org/2000/01/rdf-schema#comment | "Cardiac disease remains the leading cause of morbidity and mortality worldwide. The β1-adrenergic receptor (β1-AR) is a major regulator of cardiac functions and is downregulated in the majority of heart failure cases. A key physiological process is the activation of heterotrimeric G-protein Gs by β1-ARs, leading to increased heart rate and contractility. Here, we use cryo-electron microscopy and functional studies to investigate the molecular mechanism by which β1-AR activates Gs. We find that the tilting of α5-helix breaks a hydrogen bond between the sidechain of His373 in the C-terminal α5-helix and the backbone carbonyl of Arg38 in the N-terminal αN-helix of Gαs. Together with the disruption of another interacting network involving Gln59 in the α1-helix, Ala352 in the β6-α5 loop, and Thr355 in the α5-helix, these conformational changes might lead to the deformation of the GDP-binding pocket. Our data provide molecular insights into the activation of G-proteins by G-protein-coupled receptors."xsd:string |
| http://purl.uniprot.org/citations/32818430 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2020.08.001"xsd:string |
| http://purl.uniprot.org/citations/32818430 | http://purl.uniprot.org/core/author | "Huang J."xsd:string |
| http://purl.uniprot.org/citations/32818430 | http://purl.uniprot.org/core/author | "Liu W."xsd:string |
| http://purl.uniprot.org/citations/32818430 | http://purl.uniprot.org/core/author | "Su M."xsd:string |
| http://purl.uniprot.org/citations/32818430 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/32818430 | http://purl.uniprot.org/core/author | "Zhu L."xsd:string |
| http://purl.uniprot.org/citations/32818430 | http://purl.uniprot.org/core/author | "Walz T."xsd:string |
| http://purl.uniprot.org/citations/32818430 | http://purl.uniprot.org/core/author | "Williams D."xsd:string |
| http://purl.uniprot.org/citations/32818430 | http://purl.uniprot.org/core/author | "Huang X.Y."xsd:string |
| http://purl.uniprot.org/citations/32818430 | http://purl.uniprot.org/core/author | "Lee M.Y."xsd:string |
| http://purl.uniprot.org/citations/32818430 | http://purl.uniprot.org/core/author | "Hite R.K."xsd:string |
| http://purl.uniprot.org/citations/32818430 | http://purl.uniprot.org/core/author | "Paknejad N."xsd:string |
| http://purl.uniprot.org/citations/32818430 | http://purl.uniprot.org/core/author | "Ernst O.P."xsd:string |
| http://purl.uniprot.org/citations/32818430 | http://purl.uniprot.org/core/author | "Eng E.T."xsd:string |
| http://purl.uniprot.org/citations/32818430 | http://purl.uniprot.org/core/author | "Dey R."xsd:string |
| http://purl.uniprot.org/citations/32818430 | http://purl.uniprot.org/core/author | "Jordan K.D."xsd:string |
| http://purl.uniprot.org/citations/32818430 | http://purl.uniprot.org/core/author | "Meyerson J.R."xsd:string |
| http://purl.uniprot.org/citations/32818430 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/32818430 | http://purl.uniprot.org/core/name | "Mol Cell"xsd:string |
| http://purl.uniprot.org/citations/32818430 | http://purl.uniprot.org/core/pages | "59-71.e4"xsd:string |
| http://purl.uniprot.org/citations/32818430 | http://purl.uniprot.org/core/title | "Structural Basis of the Activation of Heterotrimeric Gs-Protein by Isoproterenol-Bound betapisub>1pi/sub>-Adrenergic Receptor."xsd:string |
| http://purl.uniprot.org/citations/32818430 | http://purl.uniprot.org/core/volume | "80"xsd:string |
| http://purl.uniprot.org/citations/32818430 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/32818430 |